Chronic myeloid leukemia CD34+cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5) P3 and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors;: effects reversed by imatinib

被引：5
作者：
Hamzah, HG
Pierce, A
Stewart, WA
Downes, CP
Gray, A
Irvine, A
Spooncer, E
Whetton, AD
机构：
[1] Univ Manchester, Fac Med, Christie Hosp, Manchester M20 9BX, Lancs, England
[2] Manchester Royal Infirm, Dept Clin Hematol, Manchester M13 9WL, Lancs, England
[3] Univ Dundee, Sch Life Sci, Dundee, Scotland
[4] Belfast City Hosp, Dept Hematol, Belfast BT9 7AD, Antrim, North Ireland
来源：
LEUKEMIA | 2005年 / 19卷 / 10期
关键词：
D O I：
10.1038/sj.leu.2403919
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：1851 / 1853
页数：4
相关论文
共 50 条
[21]   In vivo interactions of centaurin α with PtdIns(3,4,5)P3, Arf6 and actin [J].
Rodgers, EE ;
Kearns, BG ;
Donaldson, JG ;
Theibert, AB .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 :150A-150A
[22]   Orthogonal lipid sensors determine differential signaling roles of PtdIns(3,4,5)P3 and PtdIns(3,4)P2 [J].
Wang, Zhi-Gang ;
Liu, Shu-Lin ;
Cho, Wonhwa .
FASEB JOURNAL, 2017, 31
[23]   Role of Class I Myosin in Phagocytosis through PtdIns(3,4,5)P3 Signaling [J].
Chen, Chun-Lin ;
Iijima, Miho .
FASEB JOURNAL, 2011, 25
[24]   PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation [J].
Plantard, Laure ;
Arjonen, Antti ;
Lock, John G. ;
Nurani, Ghasem ;
Ivaska, Johanna ;
Stromblad, Staffan .
JOURNAL OF CELL SCIENCE, 2010, 123 (20) :3525-3534
[25]   PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development [J].
Yu, Huali ;
Wang, Nannan ;
Ju, Xingda ;
Yang, Yan ;
Sun, Dong ;
Lai, Mingming ;
Cui, Lei ;
Sheikh, Muhammad Abid ;
Zhang, Jianhua ;
Wang, Xingzhi ;
Zhu, Xiaojuan .
PLOS ONE, 2012, 7 (05)
[26]   Small chemicals with inhibitory effects on PtdIns(3,4,5) P3 binding of Btk PH domain [J].
Yoon, Youngdae .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (10) :2334-2339
[27]   Direct activation of the epithelial Na+ channel by PtdIns(3,4)P2 and PtdIns(3,4,5)P3 produced by phosphatidylinositol-3 kinase [J].
Stockand, JD ;
Shapiro, MS ;
Gamper, N ;
Tong, QS .
FASEB JOURNAL, 2004, 18 (05) :A1042-A1042
[28]   SHIP2 controls PtdIns(3,4,5)P3 levels and PKB activity in response to oxidative stress [J].
Zhang, Jing ;
Liu, Zhenan ;
Rasschaert, Joanne ;
Blero, Daniel ;
Deneubourg, Laurence ;
Schurmans, Stephane ;
Erneux, Christophe ;
Pesesse, Xavier .
CELLULAR SIGNALLING, 2007, 19 (10) :2194-2200
[29]   A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast [J].
Ross, AH ;
Mitra, P ;
Rameh, LE ;
Zhang, YJ ;
McCollum, D ;
Nunnari, JJ ;
Hendricks, GM ;
Cantley, LC .
FASEB JOURNAL, 2003, 17 (05) :A990-A990
[30]   INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor [J].
Kofuji, Satoshi ;
Kimura, Hirotaka ;
Nakanishi, Hiroki ;
Nanjo, Hiroshi ;
Takasuga, Shunsuke ;
Liu, Hui ;
Eguchi, Satoshi ;
Nakamura, Ryotaro ;
Itoh, Reietsu ;
Ueno, Noriko ;
Asanuma, Ken ;
Huang, Mingguo ;
Koizumi, Atsushi ;
Habuchi, Tomonori ;
Yamazaki, Masakazu ;
Suzuki, Akira ;
Sasaki, Junko ;
Sasaki, Takehiko .
CANCER DISCOVERY, 2015, 5 (07) :730-739
12345