Detection of ultra-low oxygen concentration based on the fluorescence blinking dynamics of single molecules

被引：7

作者：

Wu, Ruixiang ^{[1
,2
,3
]}

Chen, Ruiyun ^{[1
,2
]}

Zhou, Haitao ^{[1
,2
]}

Qin, Yaqiang ^{[1
,2
]}

Zhang, Guofeng ^{[1
,2
]}

Qin, Chengbing ^{[1
,2
]}

Gao, Yan ^{[1
,2
]}

Gao, Yajun ^{[1
,2
]}

Xiao, Liantuan ^{[1
,2
]}

Jia, Suotang ^{[1
,2
]}

机构：

[1] Shanxi Univ, Inst Laser Spect, State Key Lab Quantum Opt & Quantum Opt Devices, Taiyuan 030006, Shanxi, Peoples R China

[2] Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Shanxi, Peoples R China

[3] Shanxi Normal Univ, Coll Phys & Informat Engn, Linfen 041000, Shanxi, Peoples R China

来源：

APPLIED PHYSICS LETTERS | 2018年 / 112卷 / 05期

基金：

中国国家自然科学基金;

关键词：

DYE MOLECULES; IN-VIVO; INTERMITTENCY; TRIPLET; SENSITIVITY; KINETICS; SENSOR;

D O I：

10.1063/1.5005157

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We present a sensitive method for detection of ultra-low oxygen concentrations based on the fluorescence blinking dynamics of single molecules. The relationship between the oxygen concentration and the fraction of time spent in the off-state, stemming from the population and depopulation of triplet states and radical cationic states, can be fitted with a two-site quenching model in the Stern-Volmer plot. The oxygen sensitivity is up to 43.42 kPa(-1) in the oxygen partial pressure region as low as 0.01-0.25 kPa, which is seven times higher than that of the fluorescence intensity indicator. This method avoids the limitation of the sharp and non-ignorable fluctuations that occur during the measurement of fluorescence intensity, providing potential applications in the field of low oxygen-concentration monitoring in life science and industry. Published by AIP Publishing.

引用

页数：5

共 35 条

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