Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats

被引：104

作者：

Shimbo, M

Kawagishi, H

Yokogoshi, H ^{[1
]}

机构：

[1] Univ Shizuoka, CITY AREA, COE Program, Sch Food & Nutr Sci,Lab Nutr Biochem, Shizuoka 4228526, Japan

[2] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Shizuoka 4228529, Japan

来源：

NUTRITION RESEARCH | 2005年 / 25卷 / 06期

关键词：

erinacine A; nerve growth factor; catecholamine; hippocampus; locus coeruleus; rat;

D O I：

10.1016/j.nutres.2005.06.001

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Nerve growth factor (NGF) is an essential protein for supporting growth and maintenance of peripheral sympathetic neurons. A novel diterpenoid erinacine, isolated from the cultured mycelia of Hericium erinacium, is known to have a potent stimulating effect on NGF synthesis. The effects of erinacine and related compounds in the brain in vivo are not known. In this study, we examined the effects of erinacine A on the production of NGF and catecholamines which stimulate NGF synthesis in the brain of rats. Rats were treated with erinacine A by intubation for the first 3 weeks from birth to weaning and intragastrically from weeks 4 to 5. Rats treated with this compound had increased levels of both noradrenaline and homovanillic acid in the locus coeruleus (LC) at 4 weeks of age and increased levels of NGF in both LC and hippocampus at 5 weeks of age. The effects of erinacine A were confirmed in the central nervous system in rats. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：617 / 623

页数：7

共 24 条

[1]

AOKI C, 1992, J NEUROSCI, V12, P781

[2]

CHANPALAY V, 1991, PROG BRAIN RES, V88, P625

[3] ALZHEIMERS-DISEASE - A DISORDER OF CORTICAL CHOLINERGIC INNERVATION [J].