Neuroprotective Effect of Alpinia galanga Against Middle Cerebral Artery Occlusion- Induced Ischemia in Rat

被引：2

作者：

Farkhondeh, Tahereh ^{[1
]}

Azimi-Nezhad, Mohsen ^{[2
]}

Samini, Fariborz ^{[3
]}

Pourbagher-Shahri, Ali Mohammad ^{[4
]}

Samarghandian, Saeed ^{[2
]}

机构：

[1] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran

[2] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran

[3] Mashhad Univ Med Sci, Sch Med, Dept Neurosurg, Mashhad, Razavi Khorasan, Iran

[4] Birjand Univ Med Sci, Fac Med, Birjand, Iran

来源：

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2020年 / 10卷 / 05期

关键词：

Alpinia Galanga; Cerebral Ischemia; locomotor Functions; Middle Cerebral Artery Occlusion; Neuroprotection; TRAUMATIC BRAIN-INJURY; VOLATILE CONSTITUENTS; EXTRACT; OILS; L;

D O I：

10.33263/BRIAC105.62736281

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Alpinia galangal (A. galanga) is among the oldest traditional medications. A. galangal has important antioxidant characteristics. In the current research, we investigated the neuroprotective potential of ethanol extract of rhizomes of A. galanga in middle cerebral artery occlusion (MCAO)induced ischemia in rats. Rats were treated with A. galanga (10 and 20 mg/kg, i.p.) every 24 hours for 3 days after MCAO for 45 minutes. The behavioral impairments in rotarod performance, Angle board, and Grip test were decreased significantly in A. galanga treated rats compared to the sham- operated rats. The ischemic rats treated with A. galanga significantly improved neurobehavioral performance compared to the untreated ischemic rats. Furthermore, A. galangal treatment reduced the contralateral cortical infarct area in the MCAO rats. Our results indicated the neuroprotective properties of A. galanga in the rat model of cerebral ischemia.

引用

页码：6185 / 6193

页数：9

共 32 条

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