RNALocate v2.0: an updated resource for RNA subcellular localization with increased coverage and annotation

被引：75

作者：

Cui, Tianyu ^{[1
]}

Dou, Yiying ^{[1
]}

Tan, Puwen ^{[1
]}

Ni, Zhen ^{[2
]}

Liu, Tianyuan ^{[1
]}

Wang, DuoLin ^{[3
]}

Huang, Yan ^{[4
]}

Cai, Kaican ^{[2
]}

Zhao, Xiaoyang ^{[5
]}

Xu, Dong ^{[3
]}

Lin, Hao ^{[6
]}

Wang, Dong ^{[1
,7
]}

机构：

[1] Southern Med Univ, Sch Basic Med Sci, Dept Bioinformat, Guangzhou 510515, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Dept Thorac Surg, Guangzhou 510515, Peoples R China

[3] Univ Missouri, Bond Life Sci Ctr, Dept Elect Engn & Comp Sci, Columbia, MO 65211 USA

[4] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde Foshan 1, Foshan 528308, Peoples R China

[5] Southern Med Univ, Sch Basic Med Sci, Dept Dev Biol, State Key Lab Organ Failure Res, Guangzhou 510515, Peoples R China

[6] Univ Elect Sci & Technol China, Ctr Informat Biol, Chengdu 611731, Peoples R China

[7] Southern Med Univ, Dermatol Hosp, Guangzhou 510091, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2022年 / 50卷 / D1期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

LONG NONCODING RNAS; MESSENGER-RNA; PROTEIN LOCALIZATION; INFORMATION RESOURCE; DATABASE; REVEALS;

D O I：

10.1093/nar/gkab825

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resolving the spatial distribution of the transcriptome at a subcellular level can increase our understanding of biology and diseases. To facilitate studies of biological functions and molecular mechanisms in the transcriptome, we updated RNALocate, a resource for RNA subcellular localization analysis that is freely accessible at http://www.rnalocate.org/ or http://www.rna-society.org/rnalocate/. Compared to RNALocate v1.0, the new features in version 2.0 include (i) expansion of the data sources and the coverage of species; (ii) incorporation and integration of RNA-seq datasets containing information about subcellular localization; (iii) addition and reorganization of RNA information (RNA subcellular localization conditions and descriptive figures for method, RNA homology information, RNA interaction and ncRNA disease information) and (iv) three additional prediction tools: DM3Loc, iLoc-lncRNA and iLoc-mRNA. Overall, RNALocate v2.0 provides a comprehensive RNA subcellular localization resource for researchers to deconvolute the highly complex architecture of the cell.

引用

页码：D333 / D339

页数：7

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