Transcription factors and target genes of pre-TCR signaling

被引：10

作者：

Lopez-Rodriguez, Cristina ^{[1
,2
]}

Aramburu, Jose ^{[1
,2
]}

Berga-Bolanos, Rosa ^{[1
,2
]}

机构：

[1] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Immunol Unit, Barcelona 08003, Spain

[2] Univ Pompeu Fabra, Barcelona Biomed Res Pk, Barcelona 08003, Spain

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 12期

关键词：

Thymocyte development; Pre-TCR expression; Pre-TCR signaling; Transcription factor; Gene expression; NF-kappa B; NFATc; NFAT5; ETS1; E2A/HEB proteins; Bcl2A1; p53; Intrinsic apoptotic pathway; T-CELL-RECEPTOR; EARLY THYMOCYTE DEVELOPMENT; DOUBLE-POSITIVE THYMOCYTES; BETA-SELECTION CHECKPOINT; PROTEIN-KINASE-C; NF-KAPPA-B; BCL-2; FAMILY-MEMBERS; ADULT-MOUSE THYMUS; ROR-GAMMA-T; ALPHA-BETA;

D O I：

10.1007/s00018-015-1864-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Almost 30 years ago pioneering work by the laboratories of Harald von Boehmer and Susumo Tonegawa provided the first indications that developing thymocytes could assemble a functional TCR beta chain-containing receptor complex, the pre-TCR, before TCR alpha expression. The discovery and study of the pre-TCR complex revealed paradigms of signaling pathways in control of cell survival and proliferation, and culminated in the recognition of the multifunctional nature of this receptor. As a receptor integrated in a dynamic developmental process, the pre-TCR must be viewed not only in the light of the biological outcomes it promotes, but also in context with those molecular processes that drive its expression in thymocytes. This review article focuses on transcription factors and target genes activated by the pre-TCR to drive its different outcomes.

引用

页码：2305 / 2321

页数：17

共 214 条

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