Age-related lipid peroxidation and antioxidant enzymes in immunocompetent cells with respect to vitamin C supplementation in humans

被引：0
|
作者：
Jayachandran, M [1 ]
Samuvel, DJ [1 ]
Panneerselvam, C [1 ]
机构：
[1] Univ Madras, Dept Med Biochem, Dr ALM Post Grad Inst Basic Med Sci, Taramani 600113, Chennai, India
来源：
MEDICAL SCIENCE RESEARCH | 1998年 / 26卷 / 11期
关键词：
free radicals; immunocompetent cells; antioxidants; vitamin C; ageing; superoxide dismutase; catalase; glutathione peroxidase;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The objective of this study was to examine age-associated differences in lipid peroxidation, antioxidant enzymes and ascorbic acid in leucocytes in response to dietary vitamin C supplementation. We evaluated the efficacy of vitamin C (200 mg/day) supplementation for 30, 60 and 90 days in young and older humans. Ageing resulted in the elevation of lipid peroxidation whereas the activities of antioxidant enzymes and levels of ascorbic acid in leucocytes were lower in the older individuals. Supplementation with vitamin C resulted in lower lipid peroxidation, while enzymic antioxidant activities and ascorbic acid levels were higher in older humans. Med Sci Res 26:737-739 (C) 1998 Lippincott Williams & Wilkins.
引用
收藏
页码：737 / 739
页数：3
相关论文
共 50 条
  • [1] Antioxidant vitamin supplementation and lipid peroxidation in smokers
    Steinberg, FM
    Chait, A
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 68 (02) : 319 - 327
  • [2] The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C
    Akturk, O.
    Demirin, H.
    Sutcu, R.
    Yilmaz, N.
    Koylu, H.
    Altuntas, I.
    CELL BIOLOGY AND TOXICOLOGY, 2006, 22 (06) : 455 - 461
  • [3] The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C
    O. Akturk
    H. Demirin
    R. Sutcu
    N. Yilmaz
    H. Koylu
    I. Altuntas
    Cell Biology and Toxicology, 2006, 22
  • [4] AGE-RELATED ALTERATIONS IN ANTIOXIDANT CAPACITY AND LIPID-PEROXIDATION IN BRAIN, LIVER, AND LUNG HOMOGENATES OF NORMAL AND VITAMIN-E-DEFICIENT RATS
    MATSUO, M
    GOMI, F
    DOOLEY, MM
    MECHANISMS OF AGEING AND DEVELOPMENT, 1992, 64 (03) : 273 - 292
  • [5] Effect of short term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type -II diabetes
    Bose K.S.C.
    Agrawal B.K.
    Indian Journal of Clinical Biochemistry, 2007, 22 (1) : 95 - 98
  • [6] ANTIOXIDANT ENZYMES IN RBCS AS A BIOLOGICAL INDEX OF AGE-RELATED MACULAR DEGENERATION
    PRASHAR, S
    PANDAV, SS
    GUPTA, A
    NATH, R
    ACTA OPHTHALMOLOGICA, 1993, 71 (02): : 214 - 218
  • [7] Cadmium-induced lipid peroxidation and the antioxidant enzymes in rat tissues: Role of vitamin E and selenium
    Sarkar, S
    Poonam, Y
    Bhatnagar, D
    TRACE ELEMENTS AND ELECTROLYTES, 1997, 14 (01): : 41 - 45
  • [8] Status of lipids, lipid peroxidation, and antioxidant systems with Vitamin C supplementation during aging in rats
    Jayachandran, M
    Jayanthi, B
    Sundaravadivel, B
    Panneerselvam, C
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1996, 7 (05) : 270 - 275
  • [9] Dietary antioxidant supplementation reverses age-related neuronal changes
    O'Donnell, E
    Lynch, MA
    NEUROBIOLOGY OF AGING, 1998, 19 (05) : 461 - 467
  • [10] Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men
    Kaikkonen, J
    Porkkala-Sarataho, E
    Morrow, JD
    Roberts, LJ
    Nyyssönen, K
    Salonen, R
    Tomi-Pekka, T
    Ristonmaa, U
    Poulsen, E
    Salonen, JT
    FREE RADICAL RESEARCH, 2001, 35 (06) : 967 - 978
12345