Ifosfamide, Carboplatin and Etoposide in Recurrent Malignant Glioma

被引：13

作者：

Schaefer, N. ^{[1
]}

Tichy, J. ^{[6
]}

Thanendrarajan, S. ^{[1
,2
]}

Kim, Y. ^{[1
,2
]}

Stuplich, M. ^{[1
]}

Mack, F. ^{[1
]}

Rieger, J. ^{[6
]}

Simon, M. ^{[3
]}

Scheffler, B. ^{[4
]}

Bostroem, J. ^{[3
,5
]}

Steinbach, J. P. ^{[6
]}

Herrlinger, U. ^{[1
]}

Glas, M. ^{[1
,4
]}

机构：

[1] Univ Bonn, Med Ctr, Dept Neurol, Div Clin Neurooncol, DE-53105 Bonn, Germany

[2] Univ Bonn, Med Ctr, Dept Hematol & Oncol, DE-53105 Bonn, Germany

[3] Univ Bonn, Med Ctr, Dept Neurosurg, DE-53105 Bonn, Germany

[4] Univ Bonn, Med Ctr, Inst Reconstruct Neurobiol, DE-53105 Bonn, Germany

[5] MediClin Robert Janker Clin, Dept Radiosurg & Stereotact Radiotherapy, Bonn, Germany

[6] Goethe Univ Frankfurt, Dr Senckenbergisches Inst Neuroonkol, Frankfurt, Germany

来源：

ONCOLOGY | 2011年 / 80卷 / 5-6期

关键词：

Carboplatin; Etoposide; Ifosfamide; Recurrent glioblastoma; GLIOBLASTOMA; TEMOZOLOMIDE;

D O I：

10.1159/000330358

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

After failure of temozolomide, there is no established standard salvage chemotherapy for patients with recurrent glioblastoma (GBM). Two phase II trials combining ifosfamide, carboplatin and etoposide chemotherapy (ICE) showed favorable results. We therefore applied the ICE protocol to 13 patients (10 GBM, 3 anaplastic astrocytomas). Partial or complete remissions were not observed. None of the 13 patients survived progression-free for 6 months. Our retrospective analysis suggests that the ICE regimen is not effective in patients with recurrent high-grade glioma if applied at second or third relapse. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：330 / 332

页数：3

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