Prefrontal nicotinic receptors control novel social interaction between mice

Social behavior is a defining mammalian feature that integrates emotional and motivational processes with external rewarding stimuli. It is thus an appropriate readout for complex behaviors, yet its neuronal and molecular bases remain poorly understood. In this study, we investigated the role of the mouse prefrontal area, particularly the involvement of beta 2-subunit nicotinic receptors (beta 2*-nAChRs) in a paradigm of social behavior with concurrent motivations. We previously observed that mice lacking beta 2*-nAChRs (beta 2(-/-)) display increased time in social contact and exaggerated approach movements toward the novel conspecific. Here, combining behavioral analysis, localized brain lesions, and lentiviral gene rescue, we found that c-Fos expression is specifically activated in the prelimbic (PrL) area of the prefrontal cortex (PFC) of mice exposed to a novel conspecific; lesions of the PrL area in wild-type mice produce the same social pattern as in beta 2(-/-) mice; and virally mediated reexpression of the beta 2-subunit in the PrL area of beta 2(-/-) mice rescues behavioral components in the social interaction task up to normal levels. Together, these data reveal that social interactions particularly mobilize the PrL area of the mouse PFC and that the presence of functional PrL beta 2*-nAChRs is necessary for this integrated behavior to emerge.-Avale, M. E., Chabout, J., Pons, S., Serreau, P., De Chauont, F., Olivo-Marin, J-C., Bourgeois, J-P., Maskos, U., Changeux, J-P., Granon, S. Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J. 25, 2145-2155 (2011). www.fasebj.org