The cytotoxic T lymphocyte immune synapse at a glance

被引：68
作者：
Dieckmann, Nele M. G. [1 ]
Frazer, Gordon L. [1 ]
Asano, Yukako [1 ]
Stinchcombe, Jane C. [1 ]
Griffiths, Gillian M. [1 ]
机构：
[1] Cambridge Inst Med Res, Biomed Campus, Cambridge CB2 0XY, England
来源：
JOURNAL OF CELL SCIENCE | 2016年 / 129卷 / 15期
基金：
英国惠康基金;
关键词：
Cytotoxic T lymphocyte; Immune synapse; Secretion; CHEDIAK-HIGASHI-SYNDROME; MICROTUBULE-ORGANIZING CENTER; FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SUPRAMOLECULAR ACTIVATION CLUSTERS; NATURAL-KILLER-CELLS; IMMUNOLOGICAL SYNAPSE; GOLGI-APPARATUS; INTRAFLAGELLAR TRANSPORT; GRANULE EXOCYTOSIS; LYTIC GRANULES;
D O I：
10.1242/jcs.186205
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate focal signalling and polarised secretion in immune cells. In this Cell Science at a Glance article and the accompanying poster, we illustrate the different steps that reveal the specialised mechanisms used to focus secretion at the CTL immune synapse and allow CTLs to be such efficient and precise serial killers.
引用
收藏
页码：2881 / 2886
页数：6
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