Role of microRNA in chronic lymphocytic leukemia onset and progression

被引：62

作者：

Balatti, Veronica ^{[1
]}

Pekarky, Yuri ^{[1
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Wexner Med Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2015年 / 8卷

关键词：

microRNA; CLL; TUMOR-SUPPRESSOR; TRANSGENIC MICE; DOWN-REGULATION; TARGETING BCL2; 17P DELETION; EXPRESSION; CLL; MUTATION; DISEASE; 13Q14;

D O I：

10.1186/s13045-015-0112-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia occurring as indolent or aggressive form. CLL clinical features and genetic abnormalities are well documented, but molecular details are still under investigation. MicroRNAs are small non-coding RNAs involved in several cellular processes and expressed in a tissue-specific manner. MicroRNAs regulate gene expression, and their deregulation can alter expression levels of genes involved in development/progression of tumors. In CLL, microRNAs can function as oncogenes or tumor suppressors and can also serve as markers for CLL onset/progression. Here, we discuss the most recent findings about the role of microRNAs in CLL and how this knowledge can be used to identify new biomarkers and treatment approaches.

引用

页数：6

共 43 条

[1] Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia [J].

Allegra, D. ;

Bilan, V. ;

Garding, A. ;

Doehner, H. ;

Stilgenbauer, S. ;

Kuchenbauer, F. ;

Mertens, D. .

LEUKEMIA, 2014, 28 (01) :98-107

[2] The 13q and 11q B-cell chronic lymphocytic leukaemia-associated regions derive from a common ancestral region in the zebrafish [J].

Auer, Rebecca L. ;

Riaz, Sophia ;

Cotter, Finbarr E. .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (05) :443-453

[3] The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes [J].

Bomben, R. ;

Gobessi, S. ;

Dal Bo, M. ;

Volinia, S. ;

Marconi, D. ;

Tissino, E. ;

Benedetti, D. ;

Zucchetto, A. ;

Rossi, D. ;

Gaidano, G. ;

Del Poeta, G. ;

Laurenti, L. ;

Efremov, D. G. ;

Gattei, V. .

LEUKEMIA, 2012, 26 (07) :1584-1593

[4]

Bullrich F, 2001, MOL BIOL CHRONIC LYM, P9

[5] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[6] A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia [J].

Calin, GA ;

Ferracin, M ;

Cimmino, A ;

Di Leva, G ;

Shimizu, M ;

Wojcik, SE ;

Iorio, MV ;

Visone, R ;

Sever, NI ;

Fabbri, M ;

Iuliano, R ;

Palumbo, T ;

Pichiorri, F ;

Roldo, C ;

Garzon, R ;

Sevignani, C ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1793-1801

[7] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].

Calin, GA ;

Liu, CG ;

Sevignani, C ;

Ferracin, M ;

Felli, N ;

Dumitru, CD ;

Shimizu, M ;

Cimmino, A ;

Zupo, S ;

Dono, M ;

Dell'Aquila, ML ;

Alder, H ;

Rassenti, L ;

Kipps, TJ ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760

[8] MiR-15a and miR-16-1 cluster functions in human leukemia [J].

Calin, George A. ;

Cimmino, Amelia ;

Fabbri, Muller ;

Ferracin, Manuela ;

Wojcik, Sylwia E. ;

Shimizu, Masayoshi ;

Taccioli, Cristian ;

Zanesi, Nicola ;

Garzon, Ramiro ;

Aqeilan, Rami I. ;

Alder, Hansjuerg ;

Volinia, Stefano ;

Rassenti, Laura ;

Liu, Xiuping ;

Liu, Chang-gong ;

Kipps, Thomas J. ;

Negrini, Massimo ;

Croce, Carlo M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5166-5171

[9] The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia [J].

Calin, George A. ;

Pekarsky, Yuri ;

Croce, Carlo M. .

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2007, 20 (03) :425-437

[10] miR-15 and miR-16 induce apoptosis by targeting BCL2 [J].

Cimmino, A ;

Calin, GA ;

Fabbri, M ;

Iorio, MV ;

Ferracin, M ;

Shimizu, M ;

Wojcik, SE ;

Aqeilan, RI ;

Zupo, S ;

Dono, M ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13944-13949

← 1 2 3 4 5 →