Deficits in Functional Connectivity of Hippocampal and Frontal Lobe Circuits After Traumatic Axonal Injury

被引:89
作者
de la Plata, Carlos D. Marquez [2 ,3 ]
Garces, Juanita [1 ]
Kojori, Ehsan Shokri [3 ]
Grinnan, Jack [3 ]
Krishnan, Kamini [3 ]
Pidikiti, Rajesh [1 ]
Spence, Jeffrey [4 ]
Devous, Michael D., Sr. [5 ]
Moore, Carol [1 ]
McColl, Rodderick [5 ]
Madden, Christopher [6 ]
Diaz-Arrastia, Ramon [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA
[2] Univ Texas Dallas, Ctr Brain Hlth, Richardson, TX 75083 USA
[3] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA
[4] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA
[5] Univ Texas SW Med Ctr Dallas, Dept Radiol Neuroradiol, Dallas, TX 75390 USA
[6] Univ Texas SW Med Ctr Dallas, Dept Neurol Surg, Dallas, TX 75390 USA
基金
美国国家卫生研究院;
关键词
BLUNT HEAD-INJURY; BRAIN-INJURY; ALZHEIMERS-DISEASE; CORPUS-CALLOSUM; MEMORY DEFICIT; LESIONS; DYSFUNCTION; ATTENTION; SEVERITY; EPILEPSY;
D O I
10.1001/archneurol.2010.342
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To examine the functional connectivity of hippocampal and selected frontal lobe circuits in patients with traumatic axonal injury (TAI). Design: Observational study. Setting: An inpatient traumatic brain injury unit. Imaging and neurocognitive assessments were conducted in an outpatient research facility. Participants: Twenty-five consecutive patients with brain injuries consistent with TAI and acute subcortical white matter abnormalities were studied as well as 16 healthy volunteers of similar age and sex. Interventions: Echo-planar and high-resolution T1-weighted images were acquired using 3-T scanners. Regions of interest (ROI) were drawn bilaterally for the hippocampus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex and were used to extract time series data. Blood oxygenation level-dependent data from each ROI were used as reference functions for correlating with all other brain voxels. Interhemispheric functional connectivity was assessed for each participant by correlating homologous regions using a Pearson correlation coefficient. Patient functional and neurocognitive outcomes were assessed approximately 6 months after injury. Main Outcome Measures: Interhemispheric functional connectivity, spatial patterns of functional connectivity, and associations of connectivity measures with functional and neurocognitive outcomes. Results: Patients showed significantly lower interhemispheric functional connectivity for the hippocampus and ACC. Controls demonstrated stronger and more focused functional connectivity for the hippocampi and ACC, and a more focused recruitment of the default mode network for the dorsolateral prefrontal cortex ROI. The interhemispheric functional connectivity for the hippocampus was correlated with delayed recall of verbal information. Conclusions: Traumatic axonal injury may affect interhemispheric neural activity, as patients with TAI show disrupted interhemispheric functional connectivity. More careful investigation of interhemispheric connectivity is warranted, as it demonstrated a modest association with outcome in chronic TBI.
引用
收藏
页码:74 / 84
页数:11
相关论文
共 56 条
[1]   DIFFUSE AXONAL INJURY IN HEAD-INJURY - DEFINITION, DIAGNOSIS AND GRADING [J].
ADAMS, JH ;
DOYLE, D ;
FORD, I ;
GENNARELLI, TA ;
GRAHAM, DI ;
MCLELLAN, DR .
HISTOPATHOLOGY, 1989, 15 (01) :49-59
[2]   DIFFUSE AXONAL INJURY DUE TO NONMISSILE HEAD-INJURY IN HUMANS - AN ANALYSIS OF 45 CASES [J].
ADAMS, JH ;
GRAHAM, DI ;
MURRAY, LS ;
SCOTT, G .
ANNALS OF NEUROLOGY, 1982, 12 (06) :557-563
[3]   Reduced hippocampal functional connectivity in Alzheimer disease [J].
Allen, Greg ;
Barnard, Holly ;
McColl, Roderick ;
Hester, Andrea L. ;
Fields, Julie A. ;
Weiner, Myron F. ;
Ringe, Wendy K. ;
Lipton, Anne M. ;
Brooker, Matthew ;
McDonald, Elizabeth ;
Rubin, Craig D. ;
Cullum, C. Munro .
ARCHIVES OF NEUROLOGY, 2007, 64 (10) :1482-1487
[4]   THE COMMISSURAL CONNECTIONS OF THE MONKEY HIPPOCAMPAL-FORMATION [J].
AMARAL, DG ;
INSAUSTI, R ;
COWAN, WM .
JOURNAL OF COMPARATIVE NEUROLOGY, 1984, 224 (03) :307-336
[5]  
Arfanakis K, 2002, AM J NEURORADIOL, V23, P794
[6]   Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: A pilot study [J].
Bazarian, Jeffrey J. ;
Zhong, Jianhui ;
Blyth, Brian ;
Zhu, Tong ;
Kavcic, Voyko ;
Peterson, Derick .
JOURNAL OF NEUROTRAUMA, 2007, 24 (09) :1447-1459
[7]   Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury [J].
Benson, Randall R. ;
Meda, Shashwath A. ;
Vasudevan, Sriram ;
Kou, Zhifeng ;
Govindarajan, Koushik A. ;
Hanks, Robin A. ;
Millis, Scott R. ;
Makki, Malek ;
Latif, Zahid ;
Coplin, William ;
Meythaler, Jay ;
Haacke, E. Mark .
JOURNAL OF NEUROTRAUMA, 2007, 24 (03) :446-459
[8]  
Benton AL., 1983, Controlled oral word association test (COWAT), DOI [DOI 10.1037/T10132-000, 10.1037/t10132-000]
[9]   FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].
BISWAL, B ;
YETKIN, FZ ;
HAUGHTON, VM ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541
[10]   Synchronized brain activity and neurocognitive function in patients with low-grade glioma: A magnetoencephalography study [J].
Bosma, Ingeborg ;
Douw, Linda ;
Bartolomei, Fabrice ;
Heimans, Jan J. ;
van Dijk, Bob W. ;
Postma, Tjeerd J. ;
Stam, Cornelis J. ;
Reijneveld, Jaap C. ;
Klein, Martin .
NEURO-ONCOLOGY, 2008, 10 (05) :734-744