Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis

被引：4

作者：

Lococo, Filippo ^{[1
,2
]}

Nachira, Dania ^{[1
,2
]}

Chiappetta, Marco ^{[2
]}

Evangelista, Jessica ^{[1
,2
]}

Falcoz, Pierre Emmanuel ^{[3
]}

Ruffini, Enrico ^{[4
]}

Van Schil, Paul ^{[5
]}

Scarci, Marco ^{[6
]}

Furak, Jozsef ^{[7
]}

Sollitto, Francesco ^{[8
]}

Guerrera, Francesco ^{[4
]}

Spaggiari, Lorenzo ^{[9
]}

Aigner, Clemens ^{[10
]}

Evangelia, Liverakou ^{[11
]}

Bille, Andrea ^{[12
]}

Moser, Bernhard ^{[13
]}

Thomas, Pascal Alexandre ^{[14
]}

Liberman, Moishe ^{[15
]}

Boubia, Souheil ^{[16
]}

Campisi, Alessio ^{[17
,18
]}

Ampollini, Luca ^{[19
]}

Toker, Alper ^{[20
]}

Enyed, Attila ^{[21
]}

Voltolini, Luca ^{[22
]}

Van Raemdonck, Dirk ^{[23
]}

Margaritora, Stefano ^{[1
,2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Thorac Surgey, I-00168 Rome, Italy

[2] Fdn Policlin Univ A Gemelli IRCCS, Thorac Surg, I-00168 Rome, Italy

[3] Strasbourg Univ Hosp, Dept Surg Sci, F-67000 Strasbourg, France

[4] Univ Torino, Dept Surg Sci, I-10124 Turin, Italy

[5] Antwerp Univ, Antwerp Univ Hosp, Dept Thorac & Vasc Surg, B-2000 Antwerp, Belgium

[6] Imperial Coll NHS Healthcare Trust, Thorac Surg Divison Cardiothorac Surg, Du Cane Rd, London W12 0HS, England

[7] Univ Szeged, Dept Surg, Semmelweis U 8, H-6725 Szeged, Hungary

[8] Univ Foggia, Thorac Surg, I-71122 Foggia, Italy

[9] European Inst Oncol, Div Thorac Surg, IRCCS, IEO, I-20139 Milan, Italy

[10] Essen Univ Hosp, Dept Thorac Surg, Ruhrlandklin, D-45239 Essen, Germany

[11] Evangelismos Med Ctr, Thorac Surg Dept, Athens 10676, Greece

[12] Guys Hosp London, Thorac Surg Dept, London SE1 9RT, England

[13] Med Univ Vienna, Dept Thorac Surg, A-1090 Vienna, Austria

[14] North Hosp, Aix Marseille Univ, Dept Thorac Surg, F-13015 Marseille, France

[15] Univ Montreal, Ctr Hosp Univ Montreal, Div Thorac Surg, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada

[16] Univ Hosp Ibn Rochd Casablanca, Dept Thorac Surg, Casablanca 20250, Morocco

[17] Univ Verona, Cardiovasc & Thorac Dept, Sch Med, I-37126 Verona, Italy

[18] Verona Univ Hosp Trust, I-37126 Verona, Italy

[19] Azienda Osped Univ Parma, Unit Thorac Surg, I-43126 Parma, Italy

[20] West Virginia Univ, Dept Cardiovasc & Thorac Surg, Sch Med, Morgantown, WV 26506 USA

[21] Univ Debrecen, Fac Med, Dept Surg, 22 Moricz Zsigmond Str, H-4032 Debrecen, Hungary

[22] Careggi Univ Hosp, Thorac Surg Unit, I-50134 Florence, Italy

[23] Univ Hosp Leuven, Dept Thorac Surg, B-3000 Leuven, Belgium

来源：

DIAGNOSTICS | 2022年 / 12卷 / 07期

关键词：

thymic carcinoma; myasthenia gravis; surgery; recurrence; RETROSPECTIVE ANALYSIS; SURGICAL-TREATMENT; THYMOMA; PROGNOSIS;

D O I：

10.3390/diagnostics12071764

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II-III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG-TCs 78% vs. 50% in MG-TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients.

引用

页数：11

共 16 条

[1] Thymic carcinoma outcomes and prognosis: Results of an international analysis [J].

Ahmad, Usman ;

Yao, Xiaopan ;

Detterbeck, Frank ;

Huang, James ;

Antonicelli, Alberto ;

Filosso, Pier Luigi ;

Ruffini, Enrico ;

Travis, William ;

Jones, David R. ;

Zhan, Yilei ;

Lucchi, Marco ;

Rimner, Andreas .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2015, 149 (01) :95-+

[2] Clinical characteristics and outcomes of thymoma-associated myasthenia gravis [J].

Alvarez-Velasco, Rodrigo ;

Gutierrez-Gutierrez, Gerardo ;

Carlos Trujillo, Juan ;

Martinez, Elisabeth ;

Segovia, Sonia ;

Arribas-Velasco, Marina ;

Fernandez, Guillermo ;

Paradas, Carmen ;

Velez-Gomez, Beatriz ;

Casasnovas, Carlos ;

Nedkova, Velina ;

Guerrero-Sola, Antonio ;

Ramos-Fransi, Alba ;

Martinez-Pineiro, Alicia ;

Pardo, Julio ;

Sevilla, Teresa ;

Gomez-Caravaca, Maria Teresa ;

Lopez de Munain, Adolfo ;

Jerico, Ivonne ;

Pelayo-Negro, Ana L. ;

Asuncion Martin, Maria ;

Morgado, Yolanda ;

Dolores Mendoza, Maria ;

Perez-Perez, Helena ;

Rojas-Garcia, Ricard ;

Turon-Sans, Janina ;

Querol, Luis ;

Gallardo, Eduard ;

Illa, Isabel ;

Cortes-Vicente, Elena .

EUROPEAN JOURNAL OF NEUROLOGY, 2021, 28 (06) :2083-2091

[3] Thymic carcinoma: Current staging does not predict prognosis [J].

Blumberg, D ;

Burt, ME ;

Bains, MS ;

Downey, RJ ;

Martini, N ;

Rusch, V ;

Ginsberg, RJ .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1998, 115 (02) :303-308

[4] Thymoma and inter-relationships between clinical variables: a multicentre study in 537 patients [J].

Filosso, Pier Luigi ;

Venuta, Federico ;

Oliaro, Alberto ;

Ruffini, Enrico ;

Rendina, Erino Angelo ;

Margaritora, Stefano ;

Casadio, Caterina ;

Terzi, Alberto ;

Rena, Ottavio ;

Lococo, Filippo ;

Guerrera, Francesco .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 45 (06) :1020-1027

[5] Long-Term Survival After Surgical Treatment of Thymic Carcinoma: A Retrospective Analysis from the Chinese Alliance for Research of Thymoma Database [J].

Fu, Hao ;

Gu, Zhi-Tao ;

Fang, Wen-Tao ;

Fu, Jian-Hua ;

Shen, Yi ;

Han, Yong-Tao ;

Yu, Zhen-Tao ;

Li, Yin ;

Tan, Li-Jie ;

Pang, Lie-Wen ;

Chen, Ke-Neng .

ANNALS OF SURGICAL ONCOLOGY, 2016, 23 (02) :619-625

[6] The role of targeted therapy in thymic carcinoma [J].

Krishnan, Mridula ;

Ganti, Apar K. .

JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2019, 25 (07) :1712-1718

[7] Thymic carcinoma patients with myasthenia gravis exhibit better prognoses [J].

Li, Wenya ;

Miao, Zhifeng ;

Liu, Xudong ;

Zhang, Qigang ;

Sun, Lei ;

Li, Peiwen ;

Liu, Wenke ;

Zhang, Lin .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2016, 21 (01) :75-80

[8] Statistical primer: how to deal with missing data in scientific research? [J].

Papageorgiou, Grigorios ;

Grant, Stuart W. ;

Takkenberg, Johanna J. M. ;

Mokhles, Mostafa M. .

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2018, 27 (02) :153-158

[9] State of the art: diagnostic tools and innovative therapies for treatment of advanced thymoma and thymic carcinoma [J].

Ried, Michael ;

Marx, Alexander ;

Gotz, Andrea ;

Hamer, Okka ;

Schalke, Berthold ;

Hofmann, Hans-Stefan .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2016, 49 (06) :1545-1552

[10] Thymic Carcinoma: A Cohort Study of Patients from the European Society of Thoracic Surgeons Database [J].

Ruffini, Enrico ;

Detterbeck, Frank ;

Van Raemdonck, Dirk ;

Rocco, Gaetano ;

Thomas, Pascal ;

Weder, Walter ;

Brunelli, Alessandro ;

Guerrera, Francesco ;

Keshavjee, Shaf ;

Altorki, Nasser ;

Schuetzner, Jan ;

Arame, Alex ;

Spaggiari, Lorenzo ;

Lim, Eric ;

Toker, Alper ;

Venuta, Federico .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (04) :541-548

← 1 2 →