Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging

被引:118
作者
Dong, Jinqiao [1 ]
Pan, Yutong [1 ]
Wang, Heng [2 ]
Yang, Kuiwei [1 ]
Liu, Lingmei [3 ]
Qiao, Zhiwei [4 ]
Yuan, Yi Di [1 ]
Peh, Shing Bo [1 ]
Zhang, Jian [1 ]
Shi, Leilei [1 ]
Liang, Hong [4 ]
Han, Yu [3 ]
Li, Xiaopeng [2 ]
Jiang, Jianwen [1 ]
Liu, Bin [1 ]
Zhao, Dan [1 ]
机构
[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore
[2] Univ S Florida, Dept Chem, Tampa, FL 33620 USA
[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia
[4] Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou Key Lab New Energy & Green Catalysis, Guangzhou 510006, Peoples R China
基金
新加坡国家研究基金会; 中国国家自然科学基金;
关键词
aggregation induced emission; coordination cages; live-cell imaging; molecular rotors; self-assembly; ENANTIOSELECTIVE RECOGNITION; ORGANIC FRAMEWORKS; METALLACYCLES; FLUORESCENCE; COMPLEXES; VISCOSITY; CHANNELS; BINDING; DESIGN;
D O I
10.1002/anie.201915199
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.
引用
收藏
页码:10151 / 10159
页数:9
相关论文
共 45 条
  • [41] Atomic-resolution transmission electron microscopy of electron beam-sensitive crystalline materials
    Zhang, Daliang
    Zhu, Yihan
    Liu, Lingmei
    Ying, Xiangrong
    Hsiung, Chia-En
    Sougrat, Rachid
    Li, Kun
    Han, Yu
    [J]. SCIENCE, 2018, 359 (6376) : 675 - +
  • [42] Anion Binding in Water Drives Structural Adaptation in an Azaphosphatrane-Functionalized Fe4IIL4 Tetrahedron
    Zhang, Dawei
    Ronson, Tanya K.
    Mosquera, Jesus
    Martinez, Alexandre
    Guy, Laure
    Nitschke, Jonathan R.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (19) : 6574 - 6577
  • [43] Two-Dimensional Metal-Organic Framework with Wide Channels and Responsive Turn-On Fluorescence for the Chemical Sensing of Volatile Organic Compounds
    Zhang, Mei
    Feng, Guangxue
    Song, Zhegang
    Zhou, Yu-Peng
    Chao, Hsiu-Yi
    Yuan, Daqiang
    Tan, Tristan T. Y.
    Guo, Zhengang
    Hu, Zhigang
    Tang, Ben Zhong
    Liu, Bin
    Zhao, Dan
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (20) : 7241 - 7244
  • [44] Multicomponent Platinum(II) Cages with Tunable Emission and Amino Acid Sensing
    Zhang, Mingming
    Saha, Manik Lal
    Wang, Ming
    Zhou, Zhixuan
    Song, Bo
    Lu, Chenjie
    Yan, Xuzhou
    Li, Xiaopeng
    Huang, Feihe
    Yin, Shouchun
    Stang, Peter J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (14) : 5067 - 5074
  • [45] Highly Emissive Self-Assembled BODIPY-Platinum Supramolecular Triangles
    Zhou, Jiong
    Zhang, Yuzhen
    Yu, Guocan
    Crawley, Matthew R.
    Fulong, Cressa Ria P.
    Friedman, Alan E.
    Sengupta, Sanghamitra
    Sun, Jifu
    Li, Qing
    Huang, Feihe
    Cook, Timothy R.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (24) : 7730 - 7736