Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging

被引：117

作者：

Dong, Jinqiao ^{[1
]}

Pan, Yutong ^{[1
]}

Wang, Heng ^{[2
]}

Yang, Kuiwei ^{[1
]}

Liu, Lingmei ^{[3
]}

Qiao, Zhiwei ^{[4
]}

Yuan, Yi Di ^{[1
]}

Peh, Shing Bo ^{[1
]}

Zhang, Jian ^{[1
]}

Shi, Leilei ^{[1
]}

Liang, Hong ^{[4
]}

Han, Yu ^{[3
]}

Li, Xiaopeng ^{[2
]}

Jiang, Jianwen ^{[1
]}

Liu, Bin ^{[1
]}

Zhao, Dan ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore

[2] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia

[4] Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou Key Lab New Energy & Green Catalysis, Guangzhou 510006, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 25期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

aggregation induced emission; coordination cages; live-cell imaging; molecular rotors; self-assembly; ENANTIOSELECTIVE RECOGNITION; ORGANIC FRAMEWORKS; METALLACYCLES; FLUORESCENCE; COMPLEXES; VISCOSITY; CHANNELS; BINDING; DESIGN;

D O I：

10.1002/anie.201915199

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

引用

页码：10151 / 10159

页数：9

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