Catalytic effect of buffers on the degradation of doripenem in aqueous solutions

被引：17

作者：

Cielecka-Piontek, Judyta ^{[1
]}

Jelinska, Anna ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Fac Pharm, Dept Pharmaceut Chem, PL-60780 Poznan, Poland

来源：

REACTION KINETICS MECHANISMS AND CATALYSIS | 2011年 / 102卷 / 01期

关键词：

Doripenem; Catalytic effect of buffers; Catalytic rate constants; pH-rate profile; MEROPENEM SM-7338; SOLID-STATE; IN-VITRO; STABILITY; ERTAPENEM; CARBAPENEM; INJECTION; KINETICS;

D O I：

10.1007/s11144-010-0249-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The catalytic effect of buffers (phosphate, acetate, borate, carbonate) on the degradation of doripenem in aqueous solutions was studied at 313 K in the pH range 0.82-11.56 (mu = 0.50 mol L-1) by an HPLC-UV method developed for kinetic studies of doripenem. It was observed that general acid-base catalysis occurred in all buffers and so catalytic rate constants were calculated. Specific acid-base catalysis of doripenem involved degradation of protonated molecules and zwitter ions of doripenem catalyzed by hydrogen ions, spontaneous degradation of zwitter ions under the influence of water and degradation of zwitter ions and monoanions catalyzed by hydroxide ions.

引用

页码：37 / 47

页数：11

共 18 条

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[Anonymous], FUNDAMENTALS STABILI

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