Morphofunctional Characteristics of Fetoplacental Barrier of Placental Villi during Pregnancy Complicated by Herpes-Virus Infection

被引：1

作者：

Lutsenko, M. T. ^{[1
]}

Andrievskaya, I. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Far Eastern Res Ctr Physiol & Pathol Resp, Blagoveshchensk, Amur Region, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 04期

关键词：

herpes; syncytiotrophoblast; Bcl-2; protein; caspase-3; APOPTOSIS; BCL-2;

D O I：

10.1007/s10517-010-0987-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes virus. Increased caspase-3 activity increases the risk of DNA damage in syncytiotrophoblast nuclei.

引用

页码：537 / 539

页数：3

共 9 条

[1]

ALSOPP TE, 1995, CELL, V73, P295

[2]

ANDRIEVSKAYA IA, 2004, B FIZIOL PATOL DYKHA, P41

[3] The biochemistry of apoptosis [J].

Hengartner, MO .

NATURE, 2000, 407 (6805) :770-776

[4] The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis [J].

Kluck, RM ;

BossyWetzel, E ;

Green, DR ;

Newmeyer, DD .

SCIENCE, 1997, 275 (5303) :1132-1136

[5]

Korzhevskii D E, 2007, Morfologiia, V132, P75

[6] Aranorosin and a novel derivative inhibit the anti-apoptotic functions regulated by Bcl-2 [J].

Nakashima, Takayuki ;

Tanaka, Rieko ;

Yamashita, Yoshinori ;

Kanda, Yutaka ;

Hara, Mitsunobu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 377 (04) :1085-1090

[7]

Pogorelov V. M., 1995, GEMATOL TRANSFUSIOL, V43, P21

[8]

Protopopova N. V., 2000, METABOLISM HEMODYNAM

[9]

SOLOVEVA AS, 2007, DALNEVOST MED ZH, P22

← 1 →