Membrane-bound iron contributes to oxidative damage of β-thalassaemia intermedia erythrocytes

被引：67

作者：

Tavazzi, D ^{[1
]}

Duca, L ^{[1
]}

Graziadei, G ^{[1
]}

Comino, A ^{[1
]}

Fiorelli, G ^{[1
]}

Cappellini, MD ^{[1
]}

机构：

[1] Osped Maggiore, Policlin IRCCS, Dipartimento Med Interna, Ctr Anemie Congenite, I-20122 Milan, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 112卷 / 01期

关键词：

thalassaemia; iron; oxidative stress; erythrocyte membrane;

D O I：

10.1046/j.1365-2141.2001.02482.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Iron-dependent oxidative reactions in beta -thalassaemic erythrocyte membranes are involved in premature cell removal and anaemia. We studied 22 beta -thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described in vitro have indicators in circulating erythrocytes. Serum non-transferrin-bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane-bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non-transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron.

引用

页码：48 / 50

页数：3

共 12 条

[1] The molecular pathobiology of cell membrane iron: The sickle red cell as a model [J].