Protective mechanisms of wogonoside against Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice

被引：41
作者：
Gao, Yuan-zheng [1 ]
Zhao, Lian-feng [1 ]
Ma, Jun [1 ]
Xue, Wei-hong [1 ]
Zhao, Hui [1 ]
机构：
[1] Binzhou Med Univ, Binzhou Cent Hosp, Dept Infect Dis, Huanchengnan Rd 108, Binzhou 251700, Shandong, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 780卷
关键词：
Wogonoside; LPSNrf2; NLRP3; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; HEME OXYGENASE-1; TNF-ALPHA; OXIDATIVE STRESS; UP-REGULATION; ACID; APOPTOSIS; CELLS; INHIBITION;
D O I：
10.1016/j.ejphar.2016.02.040
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Wogonoside, a bioactive flavonoid extracted from the root of Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory and antioxidant effects. In this study, we examined the protective effects of wogonoside against lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced liver injury in mice. Mice were given an intraperitoneal injection of wogonoside 1 h before LPS and D-GalN treatment. The results showed that wogonoside inhibited the production of serum Alanine transaminase (ALT), Aspartate aminotransferase (AST), IL-1 beta, TNF-alpha, and hepatic malondialdehyde (MDA) content induced by LPS/GalN. In addition, wogonoside promoted the expression of Nrf2, NQO-1, GCLC, and HO-1. Wogonoside inhibited the expression of hepatic NLRP3, ASC, caspase-1, and IL-1 beta induced by LPS/GalN. In conclusion, these results suggest that wogonoside protects against LPS/GalN-induced acute liver injury by activating Nrf2 and inhibiting NLRP3 inflammasome activation. (C) 2016 Elsevier B.V. All rights reserved.
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页码：8 / 15
页数：8
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