THE RELATIONSHIP BETWEEN POLYMORPHISMS IN IL-6/IL-10 AND RISK OF COMMUNITY-ACQUIRED PNEUMONIA: A META-ANALYSIS

Purpose: This meta-analysis was aimed to investigate the association between polymorphisms in IL-6/IL-10 and the occurrence risk of community-acquired pneumonia (CAP). Methods: A literature search was conducted using in PubMed and Embase up to June 2019. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by using Revman 5.3. A total of 7 case-control studies contained in containing 8 articles were included in this meta-analysis. Results: The results showed no association between IL-6-174 G/C (rs1800795) and)/IL-6-572 G/C (rs1800796) gene polymorphisms polymorphism and CAP. However, there was a significant association between IL-6-174 G/C (rs1800795) and CAP when using patients without CAP as controls (GC vs. CC: P=0.03, GG + GC vs. CC: P=0.03). There was a significant association between the risk of CAP and the heterozygote gene model (GA vs. AA: P=0.01) of the IL-10-1082G/A (rs1800896) polymorphism. Meanwhile, the risk of CPA was associated with the homozygous gene model (CC vs. AA: P=0.003) of the IL-10 -592C/A (rs1800872) polymorphism. Moreover, there was a significant association between IL-10-592C/A (rs1800872) and CAP in subgroup analyses by study location of China (CC vs. CA: P=0.002, CA vs. AA: P<0.00001, CC vs. CA + AA: P=0.003). In addition, the impact of the control type (healthy control or patients without CAP) and study location (Europe or China) on the association between polymorphisms in IL-6/IL-10 and the occurrence risk of CAP were found. Conclusion: The association between polymorphisms in IL-6/IL-10 and the occurrence risk of CAP may be influenced by control type and study location. More studies should be performed to further confirm the association between IL-6/IL-10 polymorphisms and the risk of CAP.