Arteriogenesis versus angiogenesis in peripheral artery disease

被引:54
作者
Troidl, Kerstin [1 ]
Schaper, Wolfgang [1 ]
机构
[1] Max Planck Inst Heart & Lung Res, Div Arteriogenesis Res, D-61231 Bad Nauheim, Germany
关键词
arterial occlusion; arteriogenesis; fluid shear stress; nitric oxide; angiogenesis; GROWTH;
D O I
10.1002/dmrr.2232
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Different forms of vessel growth in the adult organism contribute to the compensation for an occluded artery. We here summarize the major differences between arteriogenesis and angiogenesis and provide evidence in favour of a therapeutic stimulation of collateral growth. In addition, we outline current knowledge about regulatory mechanisms transducing the initial physical stimulus into a cellular response. As an example, the role of nitric oxide during arteriogenesis is discussed, and finally, we propose a mechanism of how an efficient decision is made that makes the larger collaterals larger and the smaller ones smaller. Copyright (C) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码:27 / 29
页数:3
相关论文
共 6 条
[1]   The range of adaptation by collateral vessels after femoral artery occlusion [J].
Eitenmueller, Inka ;
Volger, Oscar ;
Kluge, Alexander ;
Troidl, Kerstin ;
Barancik, Miroslav ;
Cai, Wei-Jun ;
Heil, Matthias ;
Pipp, Frederic ;
Fischer, Silvia ;
Horrevoets, Anton J. G. ;
Schmitz-Rixen, Thomas ;
Schaper, Wolfgang .
CIRCULATION RESEARCH, 2006, 99 (06) :656-662
[2]   Elevated fluid shear stress enhances postocclusive collateral artery growth and gene expression in the pig hind limb [J].
Pipp, F ;
Boehm, S ;
Cai, WJ ;
Adili, F ;
Ziegler, B ;
Karanovic, G ;
Ritter, R ;
Balzer, J ;
Scheler, C ;
Schaper, W ;
Schmitz-Rixen, T .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (09) :1664-1668
[3]   Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model [J].
Troidl, C. ;
Nef, H. ;
Voss, S. ;
Schilp, A. ;
Kostin, S. ;
Troidl, K. ;
Szardien, S. ;
Rolf, A. ;
Schmitz-Rixen, T. ;
Schaper, W. ;
Hamm, C. W. ;
Elsaesser, A. ;
Moellmann, H. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2010, 49 (01) :142-151
[4]   Trpv4 induces collateral vessel growth during regeneration of the arterial circulation [J].
Troidl, Christian ;
Troidl, Kerstin ;
Schierling, Wilma ;
Cai, Wei-Jun ;
Nef, Holger ;
Moellmann, Helge ;
Kostin, Sava ;
Schimanski, Sylvia ;
Hammer, Linda ;
Elsaesser, Albrecht ;
Schmitz-Rixen, Thomas ;
Schaper, Wolfgang .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2009, 13 (8B) :2613-2621
[5]   Effects of Endogenous Nitric Oxide and of DETA NONOate in Arteriogenesis [J].
Troidl, Kerstin ;
Tribulova, Silvia ;
Cai, Wei-Jun ;
Rueding, Inka ;
Apfelbeck, Hanna ;
Schierling, Wilma ;
Troidl, Christian ;
Schmitz-Rixen, Thomas ;
Schaper, Wolfgang .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2010, 55 (02) :153-160
[6]   Actin-Binding Rho Activating Protein (Abra) Is Essential for Fluid Shear Stress-Induced Arteriogenesis [J].
Troidl, Kerstin ;
Rueding, Inka ;
Cai, Wei-Jun ;
Muecke, Yvonne ;
Grossekettler, Leonie ;
Piotrowska, Izabela ;
Apfelbeck, Hanna ;
Schierling, Wilma ;
Volger, Oscar L. ;
Horrevoets, Anton J. ;
Grote, Karsten ;
Schmitz-Rixen, Thomas ;
Schaper, Wolfgang ;
Troidl, Christian .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (12) :2093-U249