Ceramide in apoptosis signaling:: Relationship with oxidative stress

被引：231
|
作者：
Andrieu-Abadie, N [1 ]
Gouazé, V [1 ]
Salvayre, R [1 ]
Levade, T [1 ]
机构：
[1] CHU Rangueil, Inst Louis Bugnard, Med Biochem Lab, INSERM,U466, F-31403 Toulouse 4, France
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 31卷 / 06期
关键词：
ceramide; mitochondria; reactive oxygen species; apoptosis; free radicals;
D O I：
10.1016/S0891-5849(01)00655-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ceramide is one of the major sphingosine-based lipid second messengers that is generated in response to various extracellular agents. However, while widespread attention has focused on ceramide as a second messenger involved in the induction of apoptosis, important issues with regard to the mechanisms of ceramide formation and mode of action remain to be addressed. Several lines of evidence suggest that ceramide and oxidative stress are intimately related in cell death induction. This review focuses on the putative relationships between oxidative stress and sphingolipid metabolism in the apoptotic process and discusses the potential mechanisms that connect and regulate the two phenomena. (C) 2001 Elsevier Science Inc.
引用
收藏
页码：717 / 728
页数：12
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