Decline of ergothioneine in frailty and cognition impairment

被引:20
作者
Kondoh, Hiroshi [1 ]
Teruya, Takayuki [2 ]
Kameda, Masahiro [1 ]
Yanagida, Mitsuhiro [2 ]
机构
[1] Kyoto Univ, Grad Sch Med, Geriatr Unit, Kyoto, Japan
[2] Okinawa Inst Sci & Technol Grad Univ OIST, Cell Unit G0, Okinawa 9040495, Japan
关键词
antioxidant; dementia; ergothioneine; frailty; metabolomics; sarcopenia; starvation; whole blood; OXIDATIVE-STRESS; CALORIC RESTRICTION; FISSION YEAST; CLINICAL-PRACTICE; SCHIZOSACCHAROMYCES; METABOLITES; AGE; BIOSYNTHESIS; METABOLOMICS; VARIABILITY;
D O I
10.1002/1873-3468.14299
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ergothioneine is a well-known antioxidant that is abundant in both human red blood cells and in fission yeast responding to nutritional stress. In frail elderly people, whose ageing organs undergo functional decline, there is a correlation between ergothioneine levels and cognitive, but not skeletal muscle decline. In patients suffering from dementia, including Alzheimer's disease with hippocampal atrophy, deteriorating cognitive ability is correlated with declining ergothioneine levels. S-methyl-ergothioneine, trimethyl-histidine and three other trimethyl-ammonium compounds also decrease sharply in dementia, whereas compounds such as indoxyl-sulfate and quinolinic acid increase, possibly exacerbating the disease. Using these opposing dementia markers, not only diagnosis, but also therapeutic interventions to mitigate cognitive decline may now become possible.
引用
收藏
页码:1270 / 1278
页数:9
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