Aerobic Oxidation of Methyl-substituted β-Carbolines Catalyzed by N-Hydroxyphthalimide and Metal Catalyst

被引：10

作者：

Qiu, Hongda ^{[1
]}

Liang, Weida ^{[1
,5
]}

Zhang, Gongjun ^{[2
]}

Lin, Miaoman ^{[1
]}

Liu, Wanmin ^{[1
]}

Gao, Zhanghua ^{[1
]}

Wei, Wenting ^{[1
]}

Tang, Chunlan ^{[3
]}

Jin, Haixiao ^{[4
]}

Liang, Hongze ^{[1
]}

Yan, Xiaojun ^{[4
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Ningbo Inst Ind Technol, Ningbo 315201, Zhejiang, Peoples R China

[3] Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China

[4] Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China

[5] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 43期

基金：

中国国家自然科学基金;

关键词：

beta-carboline; Aerobic oxidation; N-Hydroxyphthalimide; Radical; Catalysis; MOLECULAR-OXYGEN; BIOLOGICAL EVALUATION; FASCAPLYSIN; DEGRADATION; ALCOHOLS; PHOTODEGRADATION; COMPLEXES; DESIGN; ROUTE; ACIDS;

D O I：

10.1002/slct.201803007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carboxylic functionalized beta-carbolines were successfully synthesized in good to excellent yields and high selectivity under mild conditions by aerobic oxidation in the presence of NHPI and transition metal salt using molecular oxygen as an oxidizing agent. A variety of derivatives of fascaplysin thus are available for structure-bioactivity investigations.

引用

页码：12363 / 12366

页数：4

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