Exophiala dermatitidis Central Line-Associated Bloodstream Infection in a Child with Ewing's Sarcoma: Case Report and Literature Review on Paediatric Infections

被引：7

作者：

Maraki, Sofia ^{[1
]}

Katzilakis, Nikolaos ^{[2
,3
]}

Neonakis, Ioannis ^{[1
]}

Stafylaki, Dimitra ^{[1
]}

Meletiadis, Joseph ^{[4
]}

Hamilos, George ^{[1
]}

Stiakaki, Eftichia ^{[2
,3
]}

机构：

[1] Univ Hosp Heraklion, Dept Clin Microbiol & Microbial Pathogenesis, Iraklion, Greece

[2] Univ Crete, Dept Pediat Hematol Oncol, Univ Hosp Heraklion, Med Sch, Iraklion, Greece

[3] Univ Crete, Med Sch, Lab Blood Dis & Childhood Canc Biol, Iraklion, Greece

[4] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Clin Microbiol Lab, Athens, Greece

来源：

MYCOPATHOLOGIA | 2022年 / 187卷 / 5-6期

关键词：

Exophiala dermatitidis; Fungemia; Paediatric fungal infections; Central line; ANTIFUNGAL SUSCEPTIBILITY; CYSTIC-FIBROSIS; THERAPY;

D O I：

10.1007/s11046-022-00658-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Exophiala dermatitidis is a dematiaceous, ubiquitous, dimorphic fungus, which can cause a wide range of invasive diseases in both immunocompromised and immunocompetent hosts. Bloodstream infections due to E. dermatitidis are rarely encountered in clinical practice, especially in pediatric patients. We describe a case of central line-associated bloodstream infection due to E. dermatitidis in a 4.5-year-old boy with Ewing's sarcoma. The fungus was isolated from blood specimens taken from the Hickman line. The isolate was identified by its phenotypic characteristics, by MALDI-TOF and by using molecular methods. The infection was successfully treated with voriconazole and catheter removal. The literature was also reviewed on pediatric infections caused by E. dermatitidis, focusing on clinical manifestations and challenges associated with diagnosis and management.

引用

页码：595 / 602

页数：8

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