Do Cytokines Contribute to the Andean-Associated Protection From Reduced Fetal Growth at High Altitude?

被引：12

作者：

Davila, R. Daniela ^{[1
,3
,5
]}

Julian, Colleen G. ^{[1
,2
]}

Wilson, Megan J. ^{[1
,2
]}

Browne, Vaughn A. ^{[1
]}

Rodriguez, Carmelo ^{[6
]}

Bigham, Abigail W. ^{[7
]}

Shriver, Mark D. ^{[7
]}

Vargas, Enrique ^{[5
]}

Moore, Lorna G. ^{[1
,4
]}

机构：

[1] Univ Colorado Denver, Altitude Res Ctr, Aurora, CO 80045 USA

[2] Univ Colorado, Dept Hlth & Behav Sci, Denver, CO 80202 USA

[3] Univ Colorado Denver, Cardiovasc Pulm Res Lab, Aurora, CO 80045 USA

[4] Wake Forest Univ, Grad Sch Arts & Sci, Winston Salem, NC 27109 USA

[5] Inst Boliviano Biol Altura, La Paz, Bolivia

[6] Clin Sirani, Santa Cruz, Bolivia

[7] Penn State Univ, Anthropl Genet Lab, State Coll, PA USA

来源：

REPRODUCTIVE SCIENCES | 2011年 / 18卷 / 01期

基金：

美国国家卫生研究院;

关键词：

cytokines; hypoxia; pregnancy; uterine artery; INFLAMMATORY CYTOKINES; OXYGEN DELIVERY; UTERINE ARTERY; PREGNANCY; HYPOXIA; PREECLAMPSIA; IMPLANTATION; RESTRICTION; REDUCTIONS; EXPOSURE;

D O I：

10.1177/1933719110380061

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Pro-versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean (AND) versus shorter duration European (EUR) high-altitude (HA) residents are protected from altitude-associated FGR. To address whether ancestry group differences in cytokine levels were involved, we conducted serial studies in 56 low-altitude ([LA]; 400 m; n=29 AND and n=27 EUR) and 42 HA residents (3600-4100 m; n=19 ANDs and n=23 EURs). Pregnancy raised pro-(interleukin 1 beta [IL-1 beta]) and anti-(IL-10) inflammatory cytokines and HA lowered IL-6 and tumor necrosis factor-alpha (TNF-alpha) near term. There were no ancestry group differences in cytokine levels at any time, but HA reduced IL-1 beta in ANDs only near term. Higher IL-1 beta levels correlated with uterine artery (UA) blood flow at 20 weeks in ANDs at HA, suggesting that IL-1 beta may play a role in AND protection from altitude-associated reductions in fetal growth.

引用

页码：79 / 87

页数：9

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