Epigenetic Modifications in Distinction: Histone versus DNA Methylation in ESCs

被引：3
|
作者：
Huang, Kevin [1 ]
Fan, Guoping [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
来源：
CELL STEM CELL | 2011年 / 8卷 / 06期
关键词：
EMBRYONIC STEM-CELLS; REQUIRES; COMPLEX;
D O I：
10.1016/j.stem.2011.05.007
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Karimi et al. (2011) show that DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) have distinct genomic targets in mouse ESCs. In particular, loss of H3K9me3 leads to derepression of select endogenous retroviruses and subsequent ectopic transcription of adjacent genes.
引用
收藏
页码：604 / 605
页数：2
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