Investigations of short-chain fatty acids in humans

被引：0

作者：

Rombeau, JL ^{[1
]}

机构：

[1] Hosp Univ Penn, Sch Med, Dept Surg, Div Colon & Rectal Surg, Philadelphia, PA 19104 USA

来源：

CLINICAL NUTRITION | 2004年

关键词：

short-chain fatty acids; butyrate;

D O I：

10.1016/j.clru.2004.09.004

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Short-chain fatty acids (SCFA) are the 2, 3 and 4 carbon saturated monocarboxylic acids produced in the human colon by bacterial. enzymatic breakdown of dietary fibre, undigested starch, and non-absorbed simple carbohydrates. They provide an important energy source for the colon and are metabolized both locally and systemically. During the past decade many studies have investigated the structural and physiologic effects of SCFA on the colon in various animal. species. More recently, important physiologic studies have been performed in humans. Additionally, the exogenous administration of SCFA to humans, particularly for those with proctosigmoiditis has been investigated. This report briefly reviews recent information concerning the physiologic effects of SCFA with particular relevance to humans. Additionally, the exogenous administration of SCFA for radiation proctitis and the possible protective role of SCFA in ulcerative colitis is discussed. Finally, suggestions for further SCFA research in humans are provided. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：19 / 23

页数：5

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