Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases

被引：6

作者：

Bilgili, S. G. ^{[1
]}

Calka, O. ^{[1
]}

Karadag, A. S. ^{[1
]}

Akdeniz, N. ^{[2
]}

Kosem, M. ^{[3
]}

机构：

[1] Yuzuncu Yil Univ, Dept Dermatol, Fac Med, TR-65300 Van, Turkey

[2] Ataturk Univ, Dept Dermatol, Fac Med, Erzurum, Turkey

[3] Yuzuncu Yil Univ, Dept Pathol, Fac Med, TR-65300 Van, Turkey

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2012年 / 31卷 / 02期

关键词：

fixed drug eruption; generalized; naproxen; nonsteroidal anti-inflammatory drug; diclofenac;

D O I：

10.1177/0960327111412804

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.

引用

页码：197 / 200

页数：4

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