The Emerging Roles of Long Noncoding RNAs as Hallmarks of Lung Cancer

被引：17

作者：

Jiang, Jun ^{[1
,2
,3
]}

Lu, Yuan ^{[2
,4
]}

Zhang, Fang ^{[2
]}

Huang, Jie ^{[4
]}

Ren, Xin-ling ^{[2
,5
]}

Zhang, Rui ^{[3
]}

机构：

[1] Fourth Mil Med Univ, Dept Hlth Serv, Xian, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pulm Med, Xian, Peoples R China

[3] Fourth Mil Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian, Peoples R China

[4] Southeast Univ, Dept Resp & Crit Care Med, Zhongda Hosp, Nanjing, Peoples R China

[5] Shenzhen Univ, Shenzhen Gen Hosp, Dept Pulm Med, Shenzhen, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

lncRNA; lung cancer; cancer treatment; prognostic biomarkers; predictive biomarkers; EPITHELIAL-MESENCHYMAL TRANSITION; PROTEIN EXPRESSION; STEM-CELLS; IN-VITRO; PROLIFERATION; PROGRESSION; METASTASIS; METABOLISM; ACTIVATION; MECHANISMS;

D O I：

10.3389/fonc.2021.761582

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Noncoding ribonucleic acids (ncRNAs) are closely associated with tumor initiation, growth, and progress in lung cancer. Long ncRNAs (lncRNAs), as one of the three subclasses of ncRNAs, play important roles in chromatin modification, transcription, and post-transcriptional processing. Various lncRNAs have recently been reported to be dysfunctional or dysregulated in cancers and have pro- or anti-tumor potential. Importantly, as a new class of cancer biomarkers, studies have demonstrated the plausibility of using certain subsets of lncRNAs as promising diagnostic, therapeutic, or prognostic strategies to manage cancers. This review focuses on lncRNAs associated with hallmarks of lung cancer, especially those discovered in the last five years. The expression levels of these lncRNAs in tumor samples are discussed, alongside their mechanisms of action, drug resistance, and potential as diagnostic and prognostic markers for lung cancer.

引用

页数：15

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