α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging

被引：75

作者：

Shrader, William D. ^{[1
]}

Amagata, Akiko ^{[1
]}

Barnes, Adam ^{[1
]}

Enns, Gregory M. ^{[3
]}

Hinman, Andrew ^{[1
]}

Jankowski, Orion ^{[1
]}

Kheifets, Viktoria ^{[1
]}

Komatsuzaki, Ryo ^{[1
]}

Lee, Edgar ^{[1
]}

Mollard, Paul ^{[1
]}

Murase, Katsuyuki ^{[1
]}

Sadun, Alfredo A. ^{[4
]}

Thoolen, Martin ^{[1
]}

Wesson, Kieron ^{[1
]}

Miller, Guy ^{[1
,2
]}

机构：

[1] Edison Pharmaceut Inc, Mountain View, CA 94043 USA

[2] Stanford Univ, Dept Anesthesiol, Stanford, CA 94305 USA

[3] Lucile Packard Childrens Hosp, Dept Pediat, Div Med Genet, Stanford, CA 94305 USA

[4] USC Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90089 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 12期

关键词：

Redox; Antioxidants; Quinone; Aging; Digital Biology; NAD(P)H-QUINONE OXIDOREDUCTASE-1 NQO1; 20S PROTEASOMAL DEGRADATION; COENZYME Q(10); VITAMIN-E; DT-DIAPHORASE; PYRROLOQUINOLINE QUINONE; CALORIC RESTRICTION; RESVERATROL; DISEASE; PLASMA;

D O I：

10.1016/j.bmcl.2011.04.085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report that alpha-tocotrienol quinone (ATQ3) is a metabolite of alpha-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3693 / 3698

页数：6

共 71 条

[1] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[2] Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects [J].

Anlasik, T ;

Sies, H ;

Griffiths, HR ;

Mecocci, P ;

Stahl, W ;

Polidori, MC .

BRITISH JOURNAL OF NUTRITION, 2005, 94 (05) :639-642

[3] 20S proteasomal degradation of ornithine decarboxylase is regulated by NQ01 [J].

Asher, G ;

Bercovich, Z ;

Tsvetkov, P ;

Shaul, Y ;

Kahana, C .

MOLECULAR CELL, 2005, 17 (05) :645-655

[4] Writing and erasing information in multilevel logic systems of a single molecule using scanning tunneling microscope [J].

Bandyopadhyay, Anirban ;

Miki, K. ;

Wakayama, Y. .

APPLIED PHYSICS LETTERS, 2006, 89 (24)

[5] A 16-bit parallel processing in a molecular assembly [J].

Bandyopadhyay, Anirban ;

Acharya, Somobrata .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (10) :3668-3672

[6] Massively parallel computing on an organic molecular layer [J].

Bandyopadhyay, Anirban ;

Pati, Ranjit ;

Sahu, Satyajit ;

Peper, Ferdinand ;

Fujita, Daisuke .

NATURE PHYSICS, 2010, 6 (05) :369-375

[7] Smallest artificial molecular neural-net for collective and emergent information processing [J].

Bandyopadhyay, Anirban ;

Sahu, Satyajit ;

Fujita, Daisuke .

APPLIED PHYSICS LETTERS, 2009, 95 (11)

[8] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[9] Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[10] The free radical theory of aging matures [J].

Beckman, KB ;

Ames, BN .

PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :547-581

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