AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus

被引：136

作者：

Coope, Andressa ^{[1
]}

Milanski, Marciane ^{[1
]}

Araujo, Eliana P. ^{[1
]}

Tambascia, Marcos ^{[1
]}

Saad, Mario J. A. ^{[1
]}

Geloneze, Bruno ^{[1
]}

Velloso, Licio A. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Dept Internal Med, Campinas, Brazil

来源：

FEBS LETTERS | 2008年 / 582卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

obesity; diabetes; hypothalamus; insulin; leptin;

D O I：

10.1016/j.febslet.2008.03.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the hypothesis that adiponectin can reproduce some of the actions of insulin/leptin in the hypothalamus. The presence of AdipoR1 and AdipoR2 was mapped to the arcuate and lateral hypothalamic nuclei. Icv adiponectin reduced food intake, which was accompanied by activation/engagement of IRS1/2, ERK, Akt, FOXO1, JAK2 and STAT3. All these actions were dependent on AdipoR1, since inhibition of this receptor, and not of AdipoR2, completely reversed the effects described above. Thus, adiponectin acts in the hypothalamus, activating elements of the canonical insulin and leptin signaling pathways and promoting reduction of food intake. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1471 / 1476

页数：6

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