A contemporary review of male breast cancer: current evidence and unanswered questions

被引：57

作者：

Leon-Ferre, Roberto A. ^{[1
]}

Giridhar, Karthik V. ^{[1
]}

Hieken, Tina J. ^{[2
]}

Mutter, Robert W. ^{[3
]}

Couch, Fergus J. ^{[4
]}

Jimenez, Rafael E. ^{[4
]}

Hawse, John R. ^{[5
]}

Boughey, Judy C. ^{[2
]}

Ruddy, Kathryn J. ^{[1
]}

机构：

[1] Mayo Clin, Dept Oncol, 200 First St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Surg, 200 First St SW, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Radiat Oncol, 200 First St SW, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Pathol, 200 First St SW, Rochester, MN 55905 USA

[5] Mayo Clin, Dept Biochem & Mol Biol, 200 First St SW, Rochester, MN 55905 USA

来源：

CANCER AND METASTASIS REVIEWS | 2018年 / 37卷 / 04期

关键词：

Male breast cancer; BRCA; Epidemiology; Surgery; Endocrine therapy; Chemotherapy; Radiation therapy; TUMOR-INFILTRATING LYMPHOCYTES; LYMPH-NODE BIOPSY; POSTMASTECTOMY RADIATION-THERAPY; FEMALE BREAST; OPEN-LABEL; FOLLOW-UP; CONSERVING SURGERY; ANDROGEN RECEPTOR; BRCA2; MUTATIONS; NEOADJUVANT CHEMOTHERAPY;

D O I：

10.1007/s10555-018-9761-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Male breast cancer is rare, accounting for 1% of all breast cancer diagnoses in the USA. Because of its rarity, most major breast cancer trials have included only female patients. This has resulted in limited prospective data to guide the clinical management of men with breast cancer. As a result, treatment decisions are typically extrapolated from data generated in female patients. This approach may be suboptimal, particularly considering the differing hormonal milieus between men and women with respect to both breast cancer development and treatment. Herein, we summarize current knowledge of the biology and clinicopathology of male breast cancer and review current approaches to locoregional and systemic management of this rare disease.

引用

页码：599 / 614

页数：16

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