Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential

被引：17

作者：

Ibrahim, Sabrin R. M. ^{[1
,2
]}

Fadil, Sana A. ^{[3
]}

Fadil, Haifa A. ^{[4
]}

Eshmawi, Bayan A. ^{[5
]}

Mohamed, Shaimaa G. A. ^{[6
]}

Mohamed, Gamal A. ^{[3
]}

机构：

[1] Batterjee Med Coll, Dept Chem, Preparatory Year Program, Jeddah 21442, Saudi Arabia

[2] Assiut Univ, Dept Pharmacognosy, Fac Pharm, Assiut 71526, Egypt

[3] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21589, Saudi Arabia

[4] Taibah Univ, Dept Clin & Hosp Pharm, Fac Pharm, Al Munawarrah 30078, Saudi Arabia

[5] King Abdulaziz Univ, Dept Pharmaceut, Fac Pharm, Jeddah 21589, Saudi Arabia

[6] British Univ, Fac Dent, Suez Desert Rd, Cairo 11837, Egypt

来源：

TOXINS | 2022年 / 14卷 / 02期

关键词：

naphthalenones; fungi; polyketides; biosynthesis; phytotoxic; bioactivities; ENDOPHYTIC FUNGUS; SECONDARY METABOLITES; NAPHTHOQUINONE DERIVATIVES; TETRACYCLIC TRITERPENOIDS; PENTAKETIDE METABOLITES; CHEMICAL-CONSTITUENTS; VERTICILLIUM-DAHLIAE; NEOFUSICOCCUM-PARVUM; MELANIN BIOSYNTHESIS; ACTIVE COMPOUNDS;

D O I：

10.3390/toxins14020154

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, including phytotoxic, neuro-protective, cytotoxic, antiviral, nematocidal, antimycobacterial, antimalarial, antimicrobial, and anti-inflammatory. The current review emphasizes the reported naphthalenone derivatives produced by various fungal species, including their sources, structures, biosynthesis, and bioactivities in the period from 1972 to 2021. Overall, more than 167 references with 159 metabolites are listed.

引用

页数：28

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