Identification of Galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain

被引：37
作者：
Mayoral, M. A. [2 ]
Mayoral, C. [1 ]
Meneses, A. [3 ]
Villalvazo, L. [4 ]
Guzman, A. [4 ]
Espinosa, B. [5 ]
Ochoa, J. L. [6 ]
Zenteno, E. [7 ]
Guevara, J. [2 ]
机构：
[1] Hosp Gen Dr Manuel Gea Gonzalez, Serv Cirug Plast & Reconstructiva, Mexico City, DF, Mexico
[2] Inst Nacl Neurol & Neurocirug, Lab Expt Enfermedades Neurodegenerativas, Mexico City 14269, DF, Mexico
[3] Inst Nacl Cancerol, Dept Patol, Mexico City, DF, Mexico
[4] Univ Nacl Autonoma Mexico, Escuela Nacl Preparatoria, Mexico City 04510, DF, Mexico
[5] Inst Nacl Enfermedades Resp, Dept Bioquim, Mexico City, DF, Mexico
[6] Ctr Invest Biol Noroeste, La Paz, Baja California, Mexico
[7] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, DF, Mexico
来源：
CANCER INVESTIGATION | 2008年 / 26卷 / 06期
关键词：
mucins; O-glycosylation; breast cancer; metastasis; lectin; Galectin-3; T-antigen;
D O I：
10.1080/07357900701837051
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that Galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fu alpha 1,2 (GalNAc alpha 1,3) Gal beta 1,4 in complex mucin) but not for Amaranthus leucocarpus (Gal beta 1,3-GalNAc-alpha 1,0-Ser/Thr) and Arachis hypogaea lectins (Gal beta 1,3GaINAc/Gal beta 1,4GlcNAc). Mucin-type glycans and Galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and Galectin-3 favor breast cancer progression and brain metastasis.
引用
收藏
页码：615 / 623
页数：9
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