Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress

被引:27
作者
Jung, Ye-Ha [2 ]
Kang, Do-Hyung [1 ]
Byun, Min Soo [1 ]
Shim, Geumsook [1 ]
Kwon, Soo Jin [2 ]
Jang, Go-Eun [2 ]
Lee, Ul Soon [3 ]
An, Seung Chan [3 ]
Jang, Joon Hwan [1 ]
Kwon, Jun Soo [1 ,2 ]
机构
[1] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul 110744, South Korea
[2] SNU MRC, Inst Neurosci, Clin Cognit Neurosci Ctr, Seoul, South Korea
[3] Korean Inst Brain Sci, Seoul, South Korea
来源
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2012年 / 15卷 / 01期
关键词
Brain-derived neurotrophic factor (BDNF); catechol O-methyl transferase (COMT); meditation; mind-body training; stress; catecholamines; BDNF VAL66MET POLYMORPHISM; HPA-AXIS REACTIVITY; COGNITIVE FUNCTION; DOPAMINE RELEASE; INTERVENTION; NEUROGENESIS; POTENTIATION; HIPPOCAMPAL; ASSOCIATION; REDUCTION;
D O I
10.3109/10253890.2011.592880
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Eighty adults (40 men, 40 women; mean age 26 years) who practiced meditation regularly and 57 healthy control adults (35 men, 22 women; mean age 26 years) participated. Plasma catecholamines (norepinephrine (NE), epinephrine (E), and dopamine (DA)) concentrations were measured, and a modified form of the Stress Response Inventory was administered. The results were analyzed using two-way analysis of covariance (ANCOVA) with control and meditation subjects, gene polymorphism as factors, and meditation duration as the covariate. Two-way ANCOVA showed a significant interaction between control and meditation subjects, and BDNF Val66Met polymorphism on DA/NE + DA/E (p = 0.042) and NE/E + NE/DA (p = 0.046) ratios. A significant interaction was found for control and meditation subjects with COMT Val158Met polymorphism and plasma NE concentrations (p = 0.009). Post hoc ANCOVA in the meditation group, adjusted for meditation duration, showed significantly higher plasma NE concentrations for COMT Met carriers than COMT Val/Val subjects (p = 0.025). Significant differences of stress levels were found between the control and meditation subjects in BDNF Val/Met (p < 0.001) and BDNF Met/Met (p = 0.003), whereas stress levels in the BDNF Val/Val genotype did not differ between the control and meditation groups. This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms.
引用
收藏
页码:97 / 104
页数:8
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