A novel synthesis of AZT

被引：15

作者：

Gauthier, C ^{[1
]}

Ramondenc, Y ^{[1
]}

Plé, G ^{[1
]}

机构：

[1] Univ Rouen, IRCOF, UPRESA UMR 6014, UFR Sci & Tech Rouen, F-76821 Mt St Aignan, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 35期

关键词：

antivirals; azides; cyclisation; nucleosides;

D O I：

10.1016/S0040-4020(01)00695-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthesis of AZT has been achieved from two commercial available products acetaldehyde and D-Mannitol. The originality of the synthesis consists of using the powerful monovinylogation reagent, the 2-lithio-1-trimethylsiloxyethylene, and to introduce the thymine moiety and to build the furanose ring in the same and last step. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7513 / 7517

页数：5

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