Association of IL28B and IL10 gene polymorphism with predisposition to tick-borne encephalitis in a Russian population

被引：20
作者：
Barkhash, Andrey V. [1 ]
Babenko, Vladimir N. [1 ,2 ]
Voevoda, Mikhail I. [1 ,2 ,3 ]
Romaschenko, Aida G. [1 ]
机构：
[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, 10 Lavrentyeva Ave, Novosibirsk 630090, Russia
[2] Novosibirsk State Univ, 2 Pirogova Str, Novosibirsk 630090, Russia
[3] Inst Internal & Prevent Med, 175-1 B Bogatkova Str, Novosibirsk 630089, Russia
来源：
TICKS AND TICK-BORNE DISEASES | 2016年 / 7卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
Tick-borne encephalitis (TBE); Human genetic predisposition; Interleukin 28B (IL28B) gene; Interleukin 10 (IL10) gene; Single nucleotide polymorphism (SNP); SINGLE NUCLEOTIDE POLYMORPHISM; HCV INFECTION; HEPATITIS-C; DISEASE; REGION; SUSCEPTIBILITY; INTERLEUKIN-10; TLR3;
D O I：
10.1016/j.ttbdis.2016.03.019
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Genetic predisposition to tick-borne encephalitis (TBE) is rather poorly studied in human populations. Human genes encoding crucial components of antiviral immune response are most likely involved in protective mechanisms against TBE virus. Previously, several single nucleotide polymorphisms (SNPs) located in interleukin 28B (IL28B) and interleukin 10 (1L10) genes were associated with predisposition to chronic hepatitis C (caused by a structurally similar virus from the same Flaviviridae family) in a number of human populations. The aim of the present study was to estimate a possible association of the IL28B gene rs8103142 and rs12980275 SNPs and IL10 gene rs1800872, rs3021094, and rs3024498 SNPs with predisposition to TBE in a Russian population. Genotypic and allelic frequencies for these SNPs were analyzed in 132 non-immunized TBE patients (34 with fever, 60 with meningitis, and 38 with severe central nervous system disease) and compared with the population control (221 Novosibirsk citizens). The results obtained suggest that both studied IL28B gene SNPs, as well as the El 0 gene rs1800872 SNP are associated with predisposition to TBE in Russian population. (C) 2016 Elsevier GmbH. All rights reserved.
引用
收藏
页码：808 / 812
页数：5
相关论文
共 20 条
[1]   Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population [J].
Barkhash, Andrey V. ;
Voevoda, Mikhail I. ;
Romaschenko, Aida G. .
ANTIVIRAL RESEARCH, 2013, 99 (02) :136-138
[2]   Single nucleotide polymorphism in the promoter region of the CD209 gene is associated with human predisposition to severe forms of tick-borne encephalitis [J].
Barkhash, Andrey V. ;
Perelygin, Andrey A. ;
Babenko, Vladimir N. ;
Brinton, Margo A. ;
Voevoda, Mikhail I. .
ANTIVIRAL RESEARCH, 2012, 93 (01) :64-68
[3]   Variability in the 2′-5′-Oligoadenylate Synthetase Gene Cluster Is Associated with Human Predisposition to Tick-Borne Encephalitis Virus-Induced Disease [J].
Barkhash, Andrey V. ;
Perelygin, Andrey A. ;
Babenko, Vladimir N. ;
Myasnikova, Natalia G. ;
Pilipenko, Pavel I. ;
Romaschenko, Aida G. ;
Voevoda, Mikhail I. ;
Brinton, Margo A. .
JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (12) :1813-1818
[4]   Human genetic susceptibility to infectious disease [J].
Chapman, Stephen J. ;
Hill, Adrian V. S. .
NATURE REVIEWS GENETICS, 2012, 13 (03) :175-188
[5]   Tick-borne encephalitis [J].
Gritsun, TS ;
Lashkevich, VA ;
Gould, EA .
ANTIVIRAL RESEARCH, 2003, 57 (1-2) :129-146
[6]   Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis [J].
Grygorczuk, Sambor ;
Parczewski, Milosz ;
Moniuszko, Anna ;
Swierzbinska, Renata ;
Kondrusik, Maciej ;
Zajkowska, Joanna ;
Czupryna, Piotr ;
Dunaj, Justyna ;
Boron-Kaczmarska, Anna ;
Pancewicz, Slawomir .
CYTOKINE, 2015, 71 (02) :125-131
[7]  
Gunther G, 2011, INFECT ECOL EPIDEMIO, V1, P6029
[8]   Host-pathogen interactions revealed by human genome-wide surveys [J].
Khor, Chiea Chuen ;
Hibberd, Martin L. .
TRENDS IN GENETICS, 2012, 28 (05) :233-243
[9]   A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis [J].
Kindberg, Elin ;
Mickiene, Aukse ;
Ax, Cecilia ;
Akerlind, Britt ;
Vene, Sirkka ;
Lindquist, Lars ;
Lundkvist, Ake ;
Svensson, Lennart .
JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (02) :266-269
[10]   A Functional Toll-Like Receptor 3 Gene (TLR3) May Be a Risk Factor for Tick-borne Encephalitis Virus (TBEV) Infection [J].
Kindberg, Elin ;
Vene, Sirkka ;
Mickiene, Aukse ;
Lundkvist, Ake ;
Lindquist, Lars ;
Svensson, Lennart .
JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (04) :523-528
12