Changing Hearts and Minds: Improving Outcomes in Cancer Treatment-Related Cardiotoxicity

被引：18

作者：

Shelburne, Nonniekaye ^{[1
,2
]}

Simonds, Naoko I. ^{[3
]}

Adhikari, Bishow ^{[4
]}

Alley, Michael ^{[5
]}

Desvigne-Nickens, Patrice ^{[4
]}

Dimond, Eileen ^{[6
]}

Filipski, Kelly ^{[1
]}

Gallicchio, Lisa ^{[1
]}

Minasian, Lori ^{[6
]}

机构：

[1] NCI, Div Canc Control & Populat Sci, Rockville, MD 20850 USA

[2] DCCPS, Clin & Translat Epidemiol Branch, 9609 Med Ctr Dr,Rm 4E110, Rockville, MD 20850 USA

[3] Sci Consulting Grp Inc, Gaithersburg, MD USA

[4] NHLBI, Div Cardiovasc Sci, Bldg 10, Bethesda, MD 20892 USA

[5] NCI, Div Canc Treatment & Diag, Rockville, MD USA

[6] NCI, Div Canc Prevent, Rockville, MD USA

来源：

CURRENT ONCOLOGY REPORTS | 2019年 / 21卷 / 01期

关键词：

Cardiotoxicity; Cancer treatment; Cardiovascular disease; Cardio-oncology; CHILDHOOD-CANCER; 5-YEAR SURVIVORS; LATE MORTALITY; CARDIOVASCULAR TOXICITY; AMERICAN-SOCIETY; RANDOMIZED-TRIAL; PREVENTION; RECOMMENDATIONS; CHEMOTHERAPY; THERAPY;

D O I：

10.1007/s11912-019-0751-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of ReviewCardiovascular effects from cancer treatment remains a leading cause of treatment-associated morbidity and mortality among cancer survivors. The National Cancer Institute and National Heart, Lung, and Blood Institute convened a Workshop in June 2018 entitled Changing Hearts and Minds: Improving Outcomes in Cancer Treatment-Related Cardiotoxicity to highlight progress, ongoing work, and update scientific priorities since the 2013 Workshop. Here we will describe these advances and provide an overview of the research priorities identified.Recent FindingsSince 2013, the National Institutes of Health has increased its support of cancer treatment-related cardiotoxicity research through the funding of grants and coordination of internal and external working groups. Workshop participants identified knowledge gaps and recommended over 20 new promising opportunities in basic and clinical cardiotoxicity research.SummarySignificant progress on mechanisms, detection, management, and prevention of cardiotoxicity has been made over the past 5years, yet some critical gaps remain.

引用

页数：9

共 40 条

[1] A Population-Based Study of Cardiovascular Mortality Following Early-Stage Breast Cancer [J].

Abdel-Qadir, Husam ;

Austin, Peter C. ;

Lee, Douglas S. ;

Amir, Eitan ;

Tu, Jack V. ;

Thavendiranathan, Paaladinesh ;

Fung, Kinwah ;

Anderson, Geoffrey M. .

JAMA CARDIOLOGY, 2017, 2 (01) :88-93

[2] Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity [J].

Aminkeng, Folefac ;

Ross, Colin J. D. ;

Rassekh, Shahrad R. ;

Hwang, Soomi ;

Rieder, Michael J. ;

Bhavsar, Amit P. ;

Smith, Anne ;

Sanatani, Shubhayan ;

Gelmon, Karen A. ;

Bernstein, Daniel ;

Hayden, Michael R. ;

Amstutz, Ursula ;

Carleton, Bruce C. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2016, 82 (03) :683-695

[3]

[Anonymous], AM COLL CARD ANN SCI

[4] Cardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention [J].

Armenian, Saro H. ;

Armstrong, Gregory T. ;

Aune, Gregory ;

Chow, Eric J. ;

Ehrhardt, Matthew J. ;

Ky, Bonnie ;

Moslehi, Javid ;

Mulrooney, Daniel A. ;

Nathan, Paul C. ;

Ryan, Thomas D. ;

van der Pal, Helena J. ;

van Dalen, Elvira C. ;

Kremer, Leontien C. M. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (21) :2135-2144

[5] Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline [J].

Armenian, Saro H. ;

Lacchetti, Christina ;

Barac, Ana ;

Carver, Joseph ;

Constine, Louis S. ;

Denduluri, Neelima ;

Dent, Susan ;

Douglas, Pamela S. ;

Durand, Jean-Bernard ;

Ewer, Michael ;

Fabian, Carol ;

Hudson, Melissa ;

Jessup, Mariell ;

Jones, Lee W. ;

Ky, Bonnie ;

Mayer, Erica L. ;

Moslehi, Javid ;

Oeffinger, Kevin ;

Ray, Katharine ;

Ruddy, Kathryn ;

Lenihan, Daniel .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (08) :893-U144

[6] Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group [J].

Armenian, Saro H. ;

Hudson, Melissa M. ;

Mulder, Renee L. ;

Chen, Ming Hui ;

Constine, Louis S. ;

Dwyer, Mary ;

Nathan, Paul C. ;

Tissing, Wim J. E. ;

Shankar, Sadhna ;

Sieswerda, Elske ;

Skinner, Rod ;

Steinberger, Julia ;

van Dalen, Elvira C. ;

van der Pal, Helena ;

Wallace, W. Hamish ;

Levitt, Gill ;

Kremer, Leontien C. M. .

LANCET ONCOLOGY, 2015, 16 (03) :E123-E136

[7] Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer [J].

Armstrong, Gregory T. ;

Chen, Yan ;

Yasui, Yutaka ;

Leisenring, Wendy ;

Gibson, Todd M. ;

Mertens, Ann C. ;

Stovall, Marilyn ;

Oeffinger, Kevin C. ;

Bhatia, Smita ;

Krull, Kevin R. ;

Nathan, Paul C. ;

Neglia, Joseph P. ;

Green, Daniel M. ;

Hudson, Melissa M. ;

Robison, Leslie L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (09) :833-842

[8] Cardioprotection and Safety of Dexrazoxane in Patients Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Advanced-Stage Lymphoblastic Non-Hodgkin Lymphoma: A Report of the Children's Oncology Group Randomized Trial Pediatric Oncology Group 9404 [J].

Asselin, Barbara L. ;

Devidas, Meenakshi ;

Chen, Lu ;

Franco, Vivian I. ;

Pullen, Jeanette ;

Borowitz, Michael J. ;

Hutchison, Robert E. ;

Ravindranath, Yaddanapudi ;

Armenian, Saro H. ;

Camitta, Bruce M. ;

Lipshultz, Steven E. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (08) :854-+

[9] Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity [J].

Avila, Monica Samuel ;

Ayub-Ferreira, Silvia Moreira ;

de Barros Wanderley, Mauro Rogerio, Jr. ;

Cruz, Fatima das Dores ;

Goncalves Brandao, Sara Michelly ;

Carvalho Rigaud, Vagner Oliveira ;

Higuchi-dos-Santos, Marilia Harumi ;

Hajjar, Ludhmila Abrahao ;

Kalil Filho, Roberto ;

Hoff, Paulo Marcelo ;

Sahade, Marina ;

Ferrari, Marcela S. M. ;

de Paula Costa, Romulo Leopoldo ;

Mano, Max Senna ;

Bittencourt Viana Cruz, Cecilia Beatriz ;

Abduch, Maria Cristina ;

Lofrano Alves, Marco Stephan ;

Guimaraes, Guilherme Veiga ;

Issa, Victor Sarli ;

Bittencourt, Marcio Sommer ;

Bocchi, Edimar Alcides .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 71 (20) :2281-2290

[10] Cardiotoxicity in a dish: new insights for personalized therapy [J].

Biermann, Mitch ;

Kamp, Timothy J. .

NATURE MEDICINE, 2016, 22 (05) :459-460

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