Chemical Constituents from Lobelia chinensis and Their Anti-virus and Anti-inflammatory Bioactivities

被引：46

作者：

Kuo, Ping-Chung ^{[2
]}

Hwang, Tsong-Long ^{[1
]}

Lin, Ying-Ting ^{[1
]}

Kuo, Yuh-Chi ^{[3
]}

Leu, Yann-Lii ^{[1
]}

机构：

[1] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[2] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[3] Fu Jen Catholic Univ, Inst Life Sci, Taipei 242, Taiwan

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 05期

关键词：

Lobelia chinensis; Lobechine; Superoxide anion generation; Elastase release; AERIAL PARTS; TYPE-1; REPLICATION; ANNONA-CHERIMOLA; GENE-EXPRESSION; FLAVONOIDS; INFLATA; LEAVES; CELLS; DERIVATIVES; ALKALOIDS;

D O I：

10.1007/s12272-011-0503-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with. compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC(50) of 6.14 +/- 1.97 mu M and lobechine (1) exhibited moderate inhibition of elastase release with IC(50) of 25.01 +/- 6.95 mu M, respectively.

引用

页码：715 / 722

页数：8

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