A local basis for progesterone action during mammary tumorigenesis - no longer RANK and file

被引:1
作者
Petrie, Whitney K. [1 ]
Hovey, Russell C. [1 ]
机构
[1] Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA
关键词
RECEPTOR ACTIVATOR; EPITHELIAL-CELLS; PROLIFERATION; LIGAND; GLAND; DIFFERENTIATION; MORPHOGENESIS; MECHANISMS; MICE;
D O I
10.1186/bcr2802
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Two recent reports provide compelling insights into the role for RANK and its ligand, RANKL, in progestin-dependent mammary tumorigenesis. These findings build upon a considerable body of evidence pointing to the RANK signaling pathway as being a key mediator of progestin action in the mammary glands.
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页数:3
相关论文
共 16 条
[1]  
[Anonymous], JAMA
[2]   Strain-Specific Differences in the Mechanisms of Progesterone Regulation of Murine Mammary Gland Development [J].
Aupperlee, Mark D. ;
Drolet, Alexis A. ;
Durairaj, Srinivasan ;
Wang, Weizhong ;
Schwartz, Richard C. ;
Haslam, Sandra Z. .
ENDOCRINOLOGY, 2009, 150 (03) :1485-1494
[3]   Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland [J].
Beleut, Manfred ;
Rajaram, Renuga Devi ;
Caikovski, Marian ;
Ayyanan, Ayyakkannu ;
Germano, Davide ;
Choi, Yongwon ;
Schneider, Pascal ;
Brisken, Cathrin .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) :2989-2994
[4]  
Calle EE, 1996, CONTRACEPTION, V54, pS1
[5]   Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors [J].
Currier, N ;
Solomon, SE ;
Demicco, EG ;
Chang, DLF ;
Farago, M ;
Ying, HQ ;
Dominguez, I ;
Sonenshein, GE ;
Cardiff, RD ;
Xiao, ZXJ ;
Sherr, DH ;
Seldin, DC .
TOXICOLOGIC PATHOLOGY, 2005, 33 (06) :726-737
[6]   The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development [J].
Fata, JE ;
Kong, YY ;
Li, J ;
Sasaki, T ;
Irie-Sasaki, J ;
Moorehead, RA ;
Elliott, R ;
Scully, S ;
Voura, EB ;
Lacey, DL ;
Boyle, WJ ;
Khokha, R ;
Penninger, JM .
CELL, 2000, 103 (01) :41-50
[7]   Transcriptional Response of the Murine Mammary Gland to Acute Progesterone Exposure [J].
Fernandez-Valdivia, Rodrigo ;
Mukherjee, Atish ;
Creighton, Chad J. ;
Buser, Adam C. ;
DeMayo, Francesco J. ;
Edwards, Dean P. ;
Lydon, John P. .
ENDOCRINOLOGY, 2008, 149 (12) :6236-6250
[8]   RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini [J].
Gonzalez-Suarez, Eva ;
Branstetter, Daniel ;
Armstrong, Allison ;
Dinh, Huyen ;
Blumberg, Hal ;
Dougall, William C. .
MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (04) :1442-1454
[9]   RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis [J].
Gonzalez-Suarez, Eva ;
Jacob, Allison P. ;
Jones, Jon ;
Miller, Robert ;
Roudier-Meyer, Martine P. ;
Erwert, Ryan ;
Pinkas, Jan ;
Branstetter, Dan ;
Dougall, William C. .
NATURE, 2010, 468 (7320) :103-+
[10]   Fatal attraction: why breast cancer cells home to bone [J].
Hofbauer, Lorenz C. ;
Rachner, Tilman ;
Singh, Shiv K. .
BREAST CANCER RESEARCH, 2008, 10 (01)