Arthritis in Kawasaki disease: A poorly recognised manifestation

被引:22
作者
Martins, Andreia [1 ]
Conde, Marta [2 ]
Brito, Maria [1 ]
Gouveia, Catarina [1 ]
机构
[1] Dona Estefania Hosp, Paediat Infect Dis Unit, Lisbon, Portugal
[2] Dona Estefania Hosp, Paediat Rheumatol Unit, Lisbon, Portugal
关键词
arthritis; intravenous immunoglobulin; Kawasaki disease; JUVENILE IDIOPATHIC ARTHRITIS; LONG-TERM MANAGEMENT; CARDIOVASCULAR-DISEASE; HEALTH-PROFESSIONALS; RHEUMATIC-FEVER; DIAGNOSIS; ENDOCARDITIS; STATEMENT; COMMITTEE; COUNCIL;
D O I
10.1111/jpc.14102
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aim: To determine the prevalence of arthritis in Kawasaki disease (KD) and the clinical characteristics of children with KD and arthritis. Methods: This was a single-centre, 15-year, retrospective study of children admitted with KD. Clinical features (including coronary involvement), laboratory results and treatment response were evaluated. Results: Of 63 children with KD, 60.3% were male, with a median of age of 2.0 years. Complete KD was found in 68.3%. The time from symptom onset to treatment was 7.0 days (median); 30.7% had coronary artery aneurysms, from which 82.5% responded to intravenous immunoglobulin. During the course of their illness, eight children developed arthritis (12.7%), which was early onset in six (75%) and oligoarticular in five (62.5%). The median number of joints was 3.5 (P-25 = 1.3, P-75 = 17.0), and at least one large joint was affected. In all cases, the arthritis was self-limited and left no sequelae, lasting a median of 14 days and no longer than 22 days. KD children with arthritis were older (P = 0.025), and those with early-onset arthritis responded to first-line therapy, unlike the late-onset group (P = 0.018). Conclusions: This study emphasises the value of a systematic articular examination of joints in KD. Refractory KD was observed in children with late-onset arthritis.
引用
收藏
页码:1371 / 1374
页数:4
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