A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases

被引：38
|
作者：
Mazzucco, S
Matà, S
Vergelli, M
Fioresi, R
Nardi, E
Mazzanti, B
Chelli, M
Lolli, F
Ginanneschi, D
Pinto, F
Massacesi, L
Papini, AM
机构：
[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50121 Florence, Italy
[2] Univ Florence, CNR, Ctr Studio Chim & Struttura Composti Eterociclici, I-50121 Florence, Italy
[3] Univ Florence, I-50121 Florence, Italy
[4] Univ Florence, Dipartartimento Sci Neurol & Psichiatr, Serv Neurofisiopatol, I-50134 Florence, Italy
[5] Univ Florence, Dipartiemento Sci Neurol & Psichiatr, I-50134 Florence, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期
关键词：
MOG; glycopeptides; multiple sclerosis; antibodies;
D O I：
10.1016/S0960-894X(98)00698-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn(31)(N-Glc)]hMOG(30-50). (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：167 / 172
页数：6
相关论文
共 50 条
  • [41] Serum neurofilament light-chain levels in children with monophasic myelin oligodendrocyte glycoprotein-associated disease, multiple sclerosis, and other acquired demyelinating syndrome
    Wendel, Eva-Maria
    Bertolini, Annikki
    Kousoulos, Lampros
    Rauchenzauner, Markus
    Schanda, Kathrin
    Wegener-Panzer, Andreas
    Baumann, Matthias
    Reindl, Markus
    Otto, Markus
    Rostasy, Kevin
    MULTIPLE SCLEROSIS JOURNAL, 2022, 28 (10) : 1553 - 1561
  • [42] Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease
    Li, Er-Chuang
    Zheng, Yang
    Cai, Meng-Ting
    Lai, Qi-Lun
    Fang, Gao-Li
    Du, Bing-Qing
    Shen, Chun-Hong
    Zhang, Yin-Xi
    Wu, Long-Jun
    Ding, Mei-Ping
    EPILEPSIA, 2022, 63 (09) : 2173 - 2191
  • [43] Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis
    Androutsou, Maria-Eleni
    Nteli, Agathi
    Gkika, Areti
    Avloniti, Maria
    Dagkonaki, Anastasia
    Probert, Lesley
    Tselios, Theodore
    Golic Grdadolnik, Simona
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (20) : 1 - 16
  • [44] Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls
    Van der Aa, A
    Hellings, N
    Bernard, CCA
    Raus, J
    Stinissen, P
    JOURNAL OF NEUROIMMUNOLOGY, 2003, 137 (1-2) : 164 - 176
  • [45] MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) GENE POLYMORPHISMS AND MULTIPLE-SCLEROSIS - NO EVIDENCE OF DISEASE ASSOCIATION WITH MOG
    ROTH, MP
    DOLBOIS, L
    BOROT, N
    PONTAROTTI, P
    CLANET, M
    COPPIN, H
    JOURNAL OF NEUROIMMUNOLOGY, 1995, 61 (02) : 117 - 122
  • [46] The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls
    Haase, CG
    Guggenmos, J
    Brehm, U
    Andersson, M
    Olsson, T
    Reindl, M
    Schneidewind, JM
    Zettl, UK
    Heidenreich, F
    Berger, T
    Wekerle, H
    Hohlfeld, R
    Linington, C
    JOURNAL OF NEUROIMMUNOLOGY, 2001, 114 (1-2) : 220 - 225
  • [47] A comparative study of hypothalamic involvement in patients with myelin oligodendrocyte glycoprotein antibody-associated disease, neuromyelitis optica spectrum disorder, and multiple sclerosis
    Luo, Wenjing
    Zhong, Xiaonan
    Shen, Shishi
    Fang, Ling
    Huang, Yiying
    Wang, Yuge
    Qiu, Wei
    EUROPEAN JOURNAL OF NEUROLOGY, 2024, 31 (09)
  • [48] Clinical practice guidelines for multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease 2023 in Japan
    Niino, Masaaki
    Isobe, Noriko
    Araki, Manabu
    Ohashi, Takashi
    Okamoto, Tomoko
    Ogino, Mieko
    Okuno, Tatsusada
    Ochi, Hirofumi
    Kawachi, Izumi
    Shimizu, Yuko
    Takahashi, Kazuya
    Takeuchi, Hideyuki
    Tahara, Masayuki
    Chihara, Norio
    Nakashima, Ichiro
    Fukaura, Hikoaki
    Misu, Tatsuro
    Miyazaki, Yusei
    Miyamoto, Katsuichi
    Mori, Masahiro
    Kinoshita, Makoto
    Takai, Yoshiki
    Fujii, Chihiro
    Watanabe, Mitsuru
    Fujihara, Kazuo
    MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2024, 90
  • [49] MRI features of myelin oligodendrocyte glycoprotein antibody disease: a descriptive study—how it differs from neuromyelitis optica spectrum disorders and multiple sclerosis
    J. Tom Mishael
    S. Sandeep
    Arun George
    Babu Philip
    Saikanth Deepalam
    Egyptian Journal of Radiology and Nuclear Medicine, 54
  • [50] Anti-NMDA receptor encephalitis concomitant with myelin oligodendrocyte glycoprotein antibody diseases A retrospective observational study
    Du, Li
    Wang, Huabing
    Zhou, Heng
    Chang, Haoxiao
    Wei, Yuzhen
    Cong, Hengri
    Xu, Wangshu
    Ma, Yuetao
    Song, Tian
    Zhang, Xinghu
    Yin, Linlin
    MEDICINE, 2020, 99 (31) : E21238
12345