A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases

被引：38
|
作者：
Mazzucco, S
Matà, S
Vergelli, M
Fioresi, R
Nardi, E
Mazzanti, B
Chelli, M
Lolli, F
Ginanneschi, D
Pinto, F
Massacesi, L
Papini, AM
机构：
[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50121 Florence, Italy
[2] Univ Florence, CNR, Ctr Studio Chim & Struttura Composti Eterociclici, I-50121 Florence, Italy
[3] Univ Florence, I-50121 Florence, Italy
[4] Univ Florence, Dipartartimento Sci Neurol & Psichiatr, Serv Neurofisiopatol, I-50134 Florence, Italy
[5] Univ Florence, Dipartiemento Sci Neurol & Psichiatr, I-50134 Florence, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期
关键词：
MOG; glycopeptides; multiple sclerosis; antibodies;
D O I：
10.1016/S0960-894X(98)00698-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn(31)(N-Glc)]hMOG(30-50). (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：167 / 172
页数：6
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