Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

被引：1033
作者：
Liu, Jiaqi [1 ]
Xiao, Qing [1 ]
Xiao, Jiani [1 ]
Niu, Chenxi [1 ]
Li, Yuanyuan [1 ]
Zhang, Xiaojun [1 ]
Zhou, Zhengwei [1 ]
Shu, Guang [1 ,2 ]
Yin, Gang [1 ,3 ]
机构：
[1] Cent South Univ, Sch Basic Med Sci, Xiangya Hosp, Dept Pathol, Changsha 410013, Peoples R China
[2] Cent South Univ, Sch Basic Med Sci, Dept Histol & Embryol, Changsha 410013, Peoples R China
[3] Cent South Univ, Sch Basic Med Sci, China Africa Res Ctr Infect Dis, Changsha 410013, Peoples R China
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2022年 / 7卷 / 01期
关键词：
PLURIPOTENT STEM-CELLS; HUMAN COLON-CANCER; BETA-CATENIN; COLORECTAL-CANCER; UP-REGULATION; BONE MASS; HEPATOCELLULAR CARCINOMAS; WNT/WINGLESS PATHWAY; INCREASED EXPRESSION; ALVEOLAR PROGENITOR;
D O I：
10.1038/s41392-021-00762-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Wnt/beta-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/beta-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/beta-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/beta-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/beta-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
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页数：23
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