Perspective: The promise of multi-cellular engineered living systems

被引：107

作者：

Kamm, Roger D. ^{[1
]}

Bashir, Rashid ^{[2
]}

Arora, Natasha ^{[1
]}

Dar, Roy D. ^{[2
]}

Gillette, Martha U. ^{[2
]}

Griffith, Linda G. ^{[1
]}

Kemp, Melissa L. ^{[3
]}

Kinlaw, Kathy ^{[4
]}

Levin, Michael ^{[5
]}

Martin, Adam C. ^{[1
]}

McDevitt, Todd C. ^{[6
]}

Nerem, Robert M. ^{[3
]}

Powers, Mark J. ^{[7
]}

Saif, Taher A. ^{[2
]}

Sharpe, James ^{[8
]}

Takayama, Shuichi ^{[3
]}

Takeuchi, Shoji ^{[9
]}

Weiss, Ron ^{[1
]}

Ye, Kaiming ^{[10
]}

Yevick, Hannah G. ^{[1
]}

Zaman, Muhammad H. ^{[11
]}

机构：

[1] MIT, Boston, MA 02139 USA

[2] Univ Illinois, Urbana, IL 61820 USA

[3] Georgia Inst Technol, Atlanta, GA 30332 USA

[4] Emory Univ, Atlanta, GA 30322 USA

[5] Tufts Univ, Boston, MA 02153 USA

[6] Gladstone Inst, San Francisco, CA 94158 USA

[7] Thermo Fisher Sci, Frederick, MD 21704 USA

[8] European Mol Biol Lab, EMBL Barcelona, Barcelona 08003, Spain

[9] Univ Tokyo, Tokyo 1138654, Japan

[10] Binghamton Univ, Binghamton, NY 13902 USA

[11] Boston Univ, Boston, MA 02215 USA

来源：

APL BIOENGINEERING | 2018年 / 2卷 / 04期

基金：

美国国家科学基金会;

关键词：

PLURIPOTENT STEM-CELLS; BLOOD-BRAIN-BARRIER; ON-A-CHIP; IN-VITRO MODEL; ENDOTHELIAL-CELLS; SELF-ORGANIZATION; DECISION-MAKING; DARCY THOMPSONS; ION CHANNELS; TISSUE;

D O I：

10.1063/1.5038337

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered. (C) 2018 Author(s).

引用

页数：21

共 157 条

[91] Three-dimensional neuron-muscle constructs with neuromuscular junctions [J].