Perspective: The promise of multi-cellular engineered living systems

被引：100

作者：

Kamm, Roger D. ^{[1
]}

Bashir, Rashid ^{[2
]}

Arora, Natasha ^{[1
]}

Dar, Roy D. ^{[2
]}

Gillette, Martha U. ^{[2
]}

Griffith, Linda G. ^{[1
]}

Kemp, Melissa L. ^{[3
]}

Kinlaw, Kathy ^{[4
]}

Levin, Michael ^{[5
]}

Martin, Adam C. ^{[1
]}

McDevitt, Todd C. ^{[6
]}

Nerem, Robert M. ^{[3
]}

Powers, Mark J. ^{[7
]}

Saif, Taher A. ^{[2
]}

Sharpe, James ^{[8
]}

Takayama, Shuichi ^{[3
]}

Takeuchi, Shoji ^{[9
]}

Weiss, Ron ^{[1
]}

Ye, Kaiming ^{[10
]}

Yevick, Hannah G. ^{[1
]}

Zaman, Muhammad H. ^{[11
]}

机构：

[1] MIT, Boston, MA 02139 USA

[2] Univ Illinois, Urbana, IL 61820 USA

[3] Georgia Inst Technol, Atlanta, GA 30332 USA

[4] Emory Univ, Atlanta, GA 30322 USA

[5] Tufts Univ, Boston, MA 02153 USA

[6] Gladstone Inst, San Francisco, CA 94158 USA

[7] Thermo Fisher Sci, Frederick, MD 21704 USA

[8] European Mol Biol Lab, EMBL Barcelona, Barcelona 08003, Spain

[9] Univ Tokyo, Tokyo 1138654, Japan

[10] Binghamton Univ, Binghamton, NY 13902 USA

[11] Boston Univ, Boston, MA 02215 USA

来源：

APL BIOENGINEERING | 2018年 / 2卷 / 04期

基金：

美国国家科学基金会;

关键词：

PLURIPOTENT STEM-CELLS; BLOOD-BRAIN-BARRIER; ON-A-CHIP; IN-VITRO MODEL; ENDOTHELIAL-CELLS; SELF-ORGANIZATION; DECISION-MAKING; DARCY THOMPSONS; ION CHANNELS; TISSUE;

D O I：

10.1063/1.5038337

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered. (C) 2018 Author(s).

引用

页数：21

共 157 条

[1] Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
Abaci, Hasan Erbil
Shuler, Michael L.
[J]. INTEGRATIVE BIOLOGY, 2015, 7 (04) : 383 - 391
[2] The old and new faces of morphology: the legacy of D'Arcy Thompson's 'theory of transformations' and 'laws of growth'
Abzhanov, Arhat
[J]. DEVELOPMENT, 2017, 144 (23): : 4284 - 4297
[3] A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood-brain barrier
Adriani, Giulia
Ma, Dongliang
Pavesi, Andrea
Kamm, Roger D.
Goh, Eyleen L. K.
[J]. LAB ON A CHIP, 2017, 17 (03) : 448 - 459
[4] Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size
Aegerter-Wilmsen, Tinri
Heimlicher, Maria B.
Smith, Alister C.
de Reuille, Pierre Barbier
Smith, Richard S.
Aegerter, Christof M.
Basler, Konrad
[J]. DEVELOPMENT, 2012, 139 (17): : 3221 - 3231
[5] Allometric scaling in-vitro
Ahluwalia, Arti
[J]. SCIENTIFIC REPORTS, 2017, 7
[6] Cell-Instructive Microgels with Tailor-Made Physicochemical Properties
Allazetta, Simone
Kolb, Laura
Zerbib, Samantha
Bardy, Jo'an
Lutolf, Matthias P.
[J]. SMALL, 2015, 11 (42) : 5647 - 5656
[7] Formation of steady-state oxygen gradients in vitro - Application to liver zonation
Allen, JW
Bhatia, SN
[J]. BIOTECHNOLOGY AND BIOENGINEERING, 2003, 82 (03) : 253 - 262
[8] Anand S. S., 2015, EXTREME MECH LETT, V8
[9] Pluripotent stem cells in disease modelling and drug discovery
Avior, Yishai
Sagi, Ido
Benvenisty, Nissim
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (03) : 170 - 182
[10] Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function
Bao, Gang
Kamm, Roger D.
Thomas, Wendy
Hwang, Wonmuk
Fletcher, Daniel A.
Grodzinsky, Alan J.
Zhu, Cheng
Mofrad, Mohammad R. K.
[J]. CELLULAR AND MOLECULAR BIOENGINEERING, 2010, 3 (02) : 91 - 105

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