An Injectable, Self-Healing Hydrogel to Repair the Central Nervous System

被引：499

作者：

Tseng, Ting-Chen ^{[1
]}

Tao, Lei ^{[2
]}

Hsieh, Fu-Yu ^{[1
]}

Wei, Yen ^{[2
]}

Chiu, Ing-Ming ^{[3
]}

Hsu, Shan-Hui ^{[1
]}

机构：

[1] Natl Taiwan Univ, Inst Polymer Sci & Engn, Taipei 10617, Taiwan

[2] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China

[3] Natl Hlth Res Inst, Inst Cellular & Syst Med, Miaoli 35053, Miaoli County, Taiwan

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 23期

基金：

美国国家科学基金会;

关键词：

STEM-CELLS; BIODEGRADABLE HYDROGELS; PORE-SIZE; CHITOSAN; DIFFERENTIATION; SCAFFOLDS; CULTURE; REGENERATION; ENGRAFTMENT; HYALURONAN;

D O I：

10.1002/adma.201500762

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An injectable, self-healing hydrogel (approximate to 1.5 kPa) is developed for healing nerve-system deficits. Neurosphere-like progenitors proliferate in the hydrogel and differentiate into neuron-like cells. In the zebrafish injury model, the central nervous system function is partially rescued by injection of the hydrogel and significantly rescued by injection of the neurosphere-laden hydrogel. The self-healing hydrogel may thus potentially repair the central nervous system.

引用

页码：3518 / 3524

页数：7

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