Pd-Catalyzed regioselective intramolecular dehydrogenative C-5 cross coupling in an N-substituted pyrrole-azole system

被引：13

作者：

Tripathi, Krishna N. ^{[1
]}

Ray, Devalina ^{[1
]}

Singh, Ravi P. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 47期

关键词：

H BOND FUNCTIONALIZATION; C-H; NATURAL-PRODUCTS; ARYLATION; INDOLES; ACTIVATION; ALKENYLATION; MOLECULES;

D O I：

10.1039/c7ob02676e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized polycyclic pyrrole-azole structures possessing fused six membered and seven membered rings were directly synthesized via ligand-enabled, Pd-catalyzed, site selective, intramolecular cross couplings of N-substituted pyrrole-azoles. C5-H activation in the presence of a reactive C2-H remains a challenge that needs to be addressed and this was targeted to be resolved through the present approach by specifically generating the cyclized products with 83-100% selectivity. The featured methodology provides a novel disconnection for the synthesis of pyrrole containing alkaloids and medicinal compounds.

引用

页码：10082 / 10086

页数：5

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