Synthesis and Suzuki-Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Halides

被引：38

作者：

Molander, Gary A. ^{[1
]}

Shin, Inji ^{[1
]}

机构：

[1] Univ Penn, Roy & Diana A Vagelos Labs, Dept Chem, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 15期

关键词：

HALO BORONIC ESTERS; PYRROLES; NITROGEN; INDOLES;

D O I：

10.1021/ol2014768

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. With this trifluoroborate, Suzuki-Miyaura cross-coupling reactions were investigated with a variety of both aryl and hetaryl chlorides in good to excellent yields.

引用

页码：3956 / 3959

页数：4

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